Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Risk Factors for Developing DILD
|
Age
Alcohol Dose Gender Genetics Pre-existing Liver Disease |
|
|
Drugs Affected by Age
|
Halothane
INH- Isoniazid Nitrofurantoin Salicylates VPA-Valproic Acid |
|
|
Drugs Affected by Alcohol
|
APAP
INH MTX |
|
|
Drugs Affected by Dose
|
APAP
ASA |
|
|
Drugs Affected by Gender
|
Azathioprine
Flucoloxacillin Halothane Methyldopa |
|
|
Drugs Affected by Genetics
|
Phenytoin
INH Sulfonamides |
|
|
Drugs Affected by Pre-existing Liver Disease
|
Niacin
MTX |
|
|
Classification of Drug Induced Injury
|
Intrinsic Hepatotoxicity
-Direct Toxins -Indirect Toxins Idiosyncratic Hepatotoxicity -Cytotoxic, Cholestatic -Damage to Hepatocytes throughout Hepatic lobule -Hypersensitivity reaction -Toxic Metabolite |
|
|
Acute Vs Chronic DILD
|
Acute: Clinical/histological evidence <3 months
Chronic: Clinical/histological evidence >3 months |
|
|
Assessment
|
Enzyme Elevation
Necrotic - AST, ALT, LDH Cholestatic - Alk Phos, 5-NC, GGT Chronic - Slight GGT, AST, ALT |
