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10 Cards in this Set

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  • Back
Risk Factors for Developing DILD
Age
Alcohol
Dose
Gender
Genetics
Pre-existing Liver Disease
Drugs Affected by Age
Halothane
INH- Isoniazid
Nitrofurantoin
Salicylates
VPA-Valproic Acid
Drugs Affected by Alcohol
APAP
INH
MTX
Drugs Affected by Dose
APAP
ASA
Drugs Affected by Gender
Azathioprine
Flucoloxacillin
Halothane
Methyldopa
Drugs Affected by Genetics
Phenytoin
INH
Sulfonamides
Drugs Affected by Pre-existing Liver Disease
Niacin
MTX
Classification of Drug Induced Injury
Intrinsic Hepatotoxicity
-Direct Toxins
-Indirect Toxins

Idiosyncratic Hepatotoxicity
-Cytotoxic, Cholestatic
-Damage to Hepatocytes throughout Hepatic lobule
-Hypersensitivity reaction
-Toxic Metabolite
Acute Vs Chronic DILD
Acute: Clinical/histological evidence <3 months

Chronic: Clinical/histological evidence >3 months
Assessment
Enzyme Elevation
Necrotic - AST, ALT, LDH

Cholestatic - Alk Phos, 5-NC, GGT

Chronic - Slight GGT, AST, ALT