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7 Cards in this Set
- Front
- Back
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powder |
refers to a chemical or mixture that is solid in physical state. |
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trituration |
the continuous rubbing or grinding of the powder in a mortar with a pestle. This method is used when working with hard, fracturable powders. |
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Pulverization by Intervention |
is used with hard crystalline powders that do not crush or triturate easily, or gummy-type substances. The first step is to use an "intervening" solvent (such as alcohol or acetone) that will dissolve the compound. The dissolved powder is then mixed in a mortar or spread on an ointment slab to enhance the evaporation of the solvent. As the solvent evaporates, the powder will recrystallize out of solution as fine particles. |
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Levigation |
reduces the particle size by triturating it in a mortar or spatulating it on an ointment slab or pad with a small amount of a liquid in which the solid is not soluble. The solvent should be somewhat viscous such as mineral oil or glycerin. This method is also used to reduce the particle size of insoluble materials when compounding ointments and suspensions. |
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granules |
particles ranging in size from about 4 to 10 mesh |
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There are three methods of commercially making compressed tablets |
The direct compression method The dry granulation method (slugging method) The wet granulation method |
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Tablets are evaluated by a variety of methods.
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Analytical determination of tablet content: Tablet hardness Tablet disintegration: Tablet dissolution: |
