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8 Cards in this Set
- Front
- Back
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Tetrodotoxin
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From Fugu, prevents voltage-gated Na+ channels in nerve cells from reaching an action potential
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Lidocain
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Prevents voltage-gated Na+ channels in nerve cells from reaching an action potential
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Tetraethylammonium (TEA)
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Blocks voltage-gated K+ channels, preventing repolarization
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Botulinus Toxin
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Blocks release of ACh from presynaptic terminals, causing total blockade of neuromuscular transmission, paralysis of skeletal muscle, and eventually death from respiratory failure
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Curare
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Competes with ACh for the nicotinic receptors on motor end plate, decreasing the size of the EPP. At maximal doses, causes paralysis and death
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AChE Inhibitors (such as neostigmine)
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Prevents degradation of ACh in synaptic cleft, proloning and enhancing the the action of ACh at the end plate. Used in treatment of myasthenia gravis
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Hemicholinium
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Blocks choline re-uptake into presynaptic terminals, reducing ACh synthesis
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Hexamethonium
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Blocks nicotinic receptors in ganglia but not motor end plate
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