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70 Cards in this Set

  • Front
  • Back
carbamazepine
strong CYP inducer
adriamycin
P-glycoprotein – substrate
amiodarone
2D6 – moderate inhibitor
use sotalol

2C9 – moderate inhibitor
use sotalol

P-glycoprotein – inhibitor
amphetamines
2D6 – major substrate
atypical antipsychotics
2D6 – major substrate
benzodiazepines (alprazolam, triazolam, diazepam, midazolam)
3A4 – major substrate

use lorazepam or oxazepam for triazolam esp.
caffeine
1A2 – major substrate
carvedilol
2C9 – major substrate
CCB (amlodipine, felodipine, diltiazem, verapamil)
3A4 – major substrate
celecoxib
2C9 – major substrate
charcoal-broiled foods
1A2 – moderate inhibitor
cigarette smoke
1A2 – moderate inhibitor
cimetidine
1A2 – moderate inhibitor
use famotidine

2C19 – moderate inhibitor
use famotidine

2D6 – moderate inhibitor
use famotidine

3A4 – moderate inhibitor
ciprofloxacin
1A2 – strong inhibitor

use another FQ
citalopram
2C19 – major substrate
clarithromycin
1A2 – moderate inhibitor
use azithromycin

3A4 – strong inhibitor

P-glycoprotein – substrate

P-glycoprotein – inhibitor
clozapine
1A2 – major substrate
codeine --> morphine
2D6 – major substrate
daunorubicin
P-glycoprotein – substrate
diazepam
2C19 – major substrate

use lora-/oxa-/tema-zepam
digoxin
P-glycoprotein – substrate
erythromycin
1A2 – moderate inhibitor
use azithromycin

3A4 – moderate inhibitor

P-glycoprotein – substrate

P-glycoprotein – inhibitor
fluconazole
2C19 – strong inhibitor
use voriconazole

3A4 – moderate inhibitor

2C9 – strong inhibitor
use voriconazole
fluoxetine
2C19 – moderate inhibitor

2C9 – major substrate

2D6 – strong inhibitor
use escitalopram
fluvastatin
2C9 – major substrate

2C9 – moderate inhibitor
fluvoxamine
1A2 – major substrate

1A2 – strong inhibitor
use escitalopram

2C19 – strong inhibitor
garlic (allicin)
strong CYP inducer
gemfibrozil
2C19 – strong inhibitor
use fenofibrate

2C9 – strong inhibitor
glimepiride
2C9 – major substrate
glipizide
2C9 – major substrate
grapefruit juice
3A4 – strong inhibitor
haloperidol
2D6 – major substrate
hydro-/oxy-codone
2D6 – major substrate
hypericum (St. John’s Wort)
strong CYP inducer
ibuprofen
2C9 – strong inhibitor

use APAP
isoniazid
2C19 – strong inhibitor

3A4 – strong inhibitor
itraconazole
3A4 – strong inhibitor
ketoconazole
1A2 – strong inhibitor
use fluconazole

2D6 – moderate inhibitor
use fluconazole

3A4 – strong inhibitor

2C9 – strong inhibitor

P-glycoprotein – inhibitor
losartan
2C9 – major substrate
methadone
2D6 – major substrate
metoprolol
2D6 – major substrate
metronidazole
3A4 – moderate inhibitor
mirtazapine
1A2 – major substrate
omeprazole
2C9 – moderate inhibitor

use lansoprazole or famotidine
oral contraceptive
1A2 – major substrate

3A4 – major substrate
paclitaxel
P-glycoprotein – substrate
paroxetine
2D6 – strong inhibitor

use escitalopram
PDE5-I (sildenafil, tadalafil, & vardenafil)
3A4 – major substrate
phenobarbital
strong CYP inducer

2C19 – major substrate
phenytoin
strong CYP inducer

2C19 – major substrate

2C9 – major substrate

P-glycoprotein – substrate

P-glycoprotein – inducer
primidone
strong CYP inducer
propranolol
1A2 – major substrate

2D6 – major substrate
protease inhibitors
3A4 – major substrate

P-glycoprotein – substrate
quinidine
2D6 – strong inhibitor

3A4 – strong inhibitor

P-glycoprotein – inhibitor
rifampin
strong CYP inducer

P-glycoprotein – inducer
ritonavir
2D6 – strong inhibitor

3A4 – strong inhibitor
sertraline
2C19 – major substrate

2D6 – moderate inhibitor
SSRIs
2D6 – major substrate
St. John’s Wort
P-glycoprotein – inducer
statins (atorvastatin, lovastatin, simvastatin)
3A4 – major substrate

use pravastatin or rosuvastatin
TCA
2D6 – major substrate
telithromycin
3A4 – strong inhibitor
theophylline
1A2 – major substrate
TMP/SMX
2C9 – major substrate

2C9 – strong inhibitor
tramadol
2D6 – major substrate
verapamil
P-glycoprotein – inhibitor
vinca alkaloids
P-glycoprotein – substrate
voriconazole
3A4 – moderate inhibitor

2C9 – major substrate
warfarin
2C9 – major substrate
zileuton
1A2 – moderate inhibitor

use montelukast