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15 Cards in this Set
- Front
- Back
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what does the initial phase of distribution dynamics reflect?
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cardiac output and regional blood flow
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what does the second phase of distribution dynamics reflect?
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rate of uptake by tissue
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apparent volume of distribution?
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an index of how widely or extensively the drug is distributed to the tissues of the body compared with the plasma
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is protein bound drug able to cross biological barriers?
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no, only free drug can pass through biological barriers
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what is included in sample taken to determine Vd?
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plasma which includes free drug and albumin-bound drug
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what is the association between Vd and T1/2?
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the greater Vd = longer half life because more widely distributed so takes body longer to clear the drug
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does acid or base tend to have a higher Vd?
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base
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how does protein binding to the drug affect the maximal intensity of action?
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binding to protein decreases the maximal intensity of action
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how does protein binding to the drug affect the elimination of the drug?
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only free drug is available for elimination
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what is consequence of sulfonamides in newborns?
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replace bilirubin and excess bilirubin goes to brain where it is toxic
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what is displacement drug interaction?
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competition between drugs for albumin binding
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what can act as drug reservoirs?
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plasma proteins, cellular reservoirs, fat, bone, transcellular
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what is required for stored drug to prolong the effects of the drug?
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if stored drug is in equilibrium with that in plasma and is released as plasma concentration declines, a concentration of the drug in plasma and at its site of action is sustained
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what is action of fat in drug reservoir and redistribution?
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can prolong drug action or terminate drug action
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what principle underlies redistribution?
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highly perfused organs are reached most quickly, then reach less perfused organs (aka redistributed)
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