Drug Discovery: Oncology

Front 1

3 phases of drug life cycle

Back 1

1.) discovery
2.) development
3.) commercial

Front 2

The stages of discovery (4)

Back 2

Targets and leads
1.) Target identification
2.) Target validation
3.) Lead generation
4.) lead optimization

all of these stages of discovery become a clinical candidate of discovery

Front 3

Target ID:
a.) Where do they come from? (3)
b.) main point

Back 3

1.) animal and cell experiments, opportunistic observations, genomics
2.) find the protein that causes the disease

Front 4

Systems biology
a.) definition

Back 4

a.) using genomics and proteomics for target identification

Front 5

Target validation
a.) example

Back 5

knockout genes, association genes

Front 6

CGH array

Back 6

comparing 2 genomes (gene validation) via amplification and deletion

Front 7

Gene expression array

Back 7

comparing 2 genomes (gene validation) via upregulation/ downregulation

Front 8

Lead generation

Back 8

Screening for drug leads, aka molecules that interact with the drug target

Front 9

Lead optimization

Back 9

testing for safety (most intensive step)

Front 10

Phase I

Back 10

oncology: For refractory patients
normal: volunteers

Front 11

FIH

Back 11

First in human study: Phase I clinical trial

Front 12

Phase II

Back 12

Efficacy: dose
normal: based on disease
oncology: based on phase I

Front 13

Phase III

Back 13

Safety and efficacy