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21 Cards in this Set

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  • Back
Two groups of bone resorption inhibitors?
biphosphonates
selective estrogen receptor
modulators
Name 7 biphosphonates?
alendronate
etidronate
ibandronate
pamidronate
risedronate
tiludronate
zoledronic acid
Name 1 selective estrogen receptor modulators?
raloxifene
What are the general uses of bone resorption inhibitors?
primarily used to treat and prevent osteoporosis due to other causes including:
corticosteroid therapy
treatment of Paget's disease
of the bone
management of hypercalcemia
Biphosphonates:
alendronate
etidronate
risedronate
tilundronate

these inhibit resorption of bone by inhibiting 1_______ _______ _____ and 2____ ____.
1. hydroxyapatite crystal dissolution
2. osteoclast activity
Which agent binds to estrogen receptors, producing estrogen-like effects on bone including decreased bone resorption and decreased bone turnover.
Raloxifene
Contraindications?
hypersensitivity
hypocalcemia
Raloxifene should not be used in women with child-bearing potential or a history of _______ disease.
thromboembolic disease
Use cautiously in patients with _____ impairment; some agents should be avoided in moderate to severe _____ impairment.
renal
renal
______ supplements decrease absorption of biphosphonates.
calcium
Tilundronate's effects may be altered by aspirin or other ______.
NSAIDs
Aspirin may increase _______ adverse reactions with alendronate.
GI
Cholestyramine (increases, decreases) absorption of raloxifene (concurrent use contraindicated)
decreases
What assessments should be done?
low bone density before and
during therapy
symptoms of Paget's disease
(bone pain, headache,
decreased visual and
auditory acuity, increased
skull size)
What are the symptoms of Paget's disease?
bone pain
headache
decreased visual
auditory acuity
increased skull size
What are lab test considerations?
monitor serum calcium in patients with osteoporosis...monitor alkaline phosphatase in patients with Paget's disease
What serum levels should be monitored in patients with osteoporosis?
calcium
What serum levels should be monitored in patients with Paget's disease?
alkaline phosphatase
List 2 potential nursing diagnoses?
Injury, risk for
Knowledge, deficient, related
to disease processes and
medication regimen
Instruct patient to take
medication exactly as
directed
Encourage patient to partici-
pate in regular exercise
and to modify behaviors
that increase the risk of
______.
osteoporosis
EVALUATION:
Clinical response to therapy can be evaluated by?
Prevention of or decrease in the progression of _____ in postmenopausal women. Decrease in the progression of _____ disease.
osteoporosis
Paget's