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28 Cards in this Set

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Name 3 groups of antiretrovirals.
non-nucleoside reverse
transcriptase inhibitors
nucleoside reverse
transcriptase inhibitors
protease inhibitors
Name 3 non-nucleoside reverse transciptase inhibitors?
delavirdine Rescriptor

efavirenz Sustiva

nevirapine Viramune
Name 6 nucleoside reverse transcriptase inhibitors?
abacavir Ziagen

didanosine ddl,
dideoxyinosine, Videx, Videx EC

lamivudine Epivir, Epivir HBV, 3TC

stavudine d4T, Zerit, Zerit XR

tenofovir disoproxil fumarate
Viread

zidovudine {Apo-Zidovudine}, azidothymidine, AZT, {Novo-AZT}, Retrovir
Name 6 protease inhibitors?
amprenavir Agenerase

indinavir Crixivan

lopinavir/ritonavir
Kaletra

nelfinavir Viracept

ritonavir Norvir

saquinavir Fortovase, Invirase
Antiretrovirals are used in the management of ____ infection.
HIV
Antiretrovirals improve ____ cell counts and ____ viral load.
CD4

decrease
If accomplished, this generally results in slowed progression of the disease, improved quality of life, and decreased _______ infections.
opportunistic
Perinatal use of agents also prevents transmission of the virus to the _____.
fetus
Post-exposure ______ with antiretrovirals is also recommended.
prophylaxis
Because of the rapid emergence of ______ and _____ of individual agents, HIV infection is almost always managed by a combination of agents.
resistance

toxicities
Selections and doses are based on individual _____, underlying organ system disease, concurrent drug therapy, and severity of illness.
toxicities
Up to how many agents may be used simultaneously?
4

(More than 100 agents are currently being tested in addition to those already approved by FDA
Contraindications to retrovirals include?
hypersensitivity

(due to highly varying toxicities, there are many more, so refer to individual monographs)
Many antiretrovirals require modification for ____ impairment.
renal
Protease inhibitors may cause _____ and should be used cautiously in patients with diabetes.
hyperglycemia
______ may also be at risk of bleeding when taking protease inhibitors.
Hemophiliacs
There are many significant and potentially serious _____-____ interactions among antiretrovirals.
drug-drug
Assess patient for change in severity of symptoms of ____ and for symptoms of opportunistic infections throughout therapy.
HIV
Monitor ____ load and ____ counts prior to and periodically during therapy.
viral

CD4
3 potential nursing diagnoses?
Infection, risk for
Knowledge, deficient, related
to disease processes and
medication regimen
Noncompliance
When should doses be administered?
around the clock
Antiretrovirals should not be shared with others. Instruct patient to take medication exactly as directed, around the clock, even if sleep is interrupted. Emphasize the importance of complying with therapy, not taking more than prescribed amount, and not discontinuing without consulting hcp. Patient should not double doses. Long-term effects are unknown. What should patient do if a dose is missed?
Missed doses should be taken as soon as remembered unless almost time for next dose.
Inform patient that antiretroviral therapy does not cure ____ and does not reduce the risk of HIV to others through sexual contact or blood contamination.
HIV
Caution patient to use a _____ during sexual contact.
condom
Caution patient to avoid sharing needles or donating blood to prevent spreading the ____ virus to others.
AIDS
Advise patient to avoid taking any ___ or ____ medications or herbal or alternative therapies without consulting hcp.
RX or OTC
Emphasize the importance of regular follow-up exams and ___ ____ to determine progress and monitor for side effects.
blood counts
Effectiveness of therapy can be demonstrated by a decrease in ____ ____ and increase in ___ counts in patients with HIV.
viral load

CD4