Drug Class - Antiasthmatics

Front 1

What are antiasthmatics used for?

Back 1

management of acute and
chronic episodes of
reversible broncho-
constriction

Front 2

Goal of antiasthmatic agents is to?
Hint: short-term and long-
term goal

Back 2

treat acute attacks (short-term control) and to decrease incidence and intensity of future attacks (long-term control)

Front 3

The choice of modalities depends on the continued requirement for ____ _____ control agents.

Back 3

short term

Front 4

Which two types of antiasthmatics work by increasing intracellular levels of cyclic-3', 5' adenosine monophosphate (cAMP)?

Back 4

1. adrenergic
bronchodilators
(by increasing production)

2. phosphodiesterase
inhibitors
(by decreasing breakdown)

(increased levels of cAMP produce BRONCHODILATION)

Front 5

How do corticosteroids work?

Back 5

by decreasing airway inflammation

Front 6

How do anticholinergics (ipratropium) produce bronchodilation?

Back 6

by decreasing intracellular levels of cyclic guanosine monophosphate (cGMP)

Front 7

How do leukotriene receptor antagonists and mast cell stabilizers work?

Back 7

by decreasing the release of substances that can contribute to bronchospasm

Front 8

Which antiasthmatics should not be used during acute attacks of asthma? (3)

Back 8

inhaled corticosteroids
long-acting adrenergic agents
mast cell stabilizers

Front 9

Which 2 antiasthmatics should be used cautiously in patients with cardiovascular disease?

Back 9

adrenergic bronchodilators
anticholinergics

Front 10

Chronic use of which antiasthmatics should be AVOIDED in children or during pregnancy or lactation? (1)

Back 10

systemic corticosteroids

Front 11

Which antiasthmatic drug should never be abruptly discontinued?

Back 11

corticosteroids

Front 12

Which two antiasthmatics may have additive CNS and cardiovascular effects with other adrenergic agents?

Back 12

adrenergic bronchodilators
phosphodiesterase inhibitors

Front 13

Which particular antiasthmatic increases theophylline levels and the risk of toxicity?

Back 13

cimetidine

Front 14

Which group of antiasthmatics may decrease the effectiveness of antidiabetic agents?

Back 14

corticosteroids

Front 15

Corticosteroids may cause _____ which may be additive with potassium-losing diuretics and may also increase the risk of digoxin toxicity.

Back 15

hypokalemia

Front 16

While taking antiasthmatics, assess ______ ______ and _____ _____ prior to and periodically throughout therapy.

Back 16

lung sounds
respiratory function

Front 17

What should be assessed and monitored while taking adrenergic bronchodilators or anticholinergics?

Back 17

cardiovascular status by monitoring ECG changes and chest pain

Front 18

Potential Nursing Diagnoses? (3)

Back 18

Ineffective airway clearance
Knowledge deficit, related to
medication regimen
Noncompliance

Front 19

Patient/Family teaching tips?

Back 19

take meds as directed

avoid smoking and respiratory
irritants

teach metered-dose inhaler
techniques

contact hcp if:
med doesn't work
symptoms worsen after
treatment
toxic effects occur

if using inhalation meds and
bronchodilators, use
bronchodilators FIRST and
allow 5 minutes to elapse
before taking other meds
unless advised otherwise
by hcp

Front 20

Clinical response is indicated by?

Back 20

prevention of and reduction in symptoms of asthma

Front 21

Four groups of antiasthmatics are?

Back 21

bronchodilators
corticosteroids
leukotriene receptor
antagonists
mast cell stabilizers

Front 22

Name 8 bronchodilators?

Back 22

albuterol AccuNeb, Airet, {Gen-Salbutamol}, {Novo-Salmol}, Proventil, Proventil HFA, salbutamol, Ventodisk, Ventolin, Ventolin HFA, Volmax, VoSpira ER

epinephrine Adrenalin, Ana-Guard, AsthmaHaler Mist, AsthmaNefrin(racepinephrine), EpiPen, microNefrin, Nephron, Primatene, Sus-Phrine, S-2

formoterol Foradil

levalbuterol Xopenex

metaproterenol Alupent

pirbuterol Maxair

salmeterol Serevent

terbutaline Brethaire, Bricanyl

Front 23

Name 12 corticosteroids?

Back 23

alclometasone
TOPICAL/LOCAL: Aclovate

amcinonide
TOPICAL/LOCAL: Cyclocort

beclomethasone
INHALATION: {Beclodisk}, {Becloforte}, QVAR
NASAL: Beconase, Beconase AQ, Vancenase, Vancenase AQ 84 mcg

betamethasone
LONG-ACTING SYSTEMIC: {Betnelan}, {Betnesol}, Celestone, Cel-U-Jec, {Selestoject}
TOPICAL/LOCAL: Alphatrex, Beben, {Betacort}, {Betaderm}, Betatrex, Beta-Val, {Betnovate}, {Celestoderm}, Dermabet, Diprolene, Diprosone, {Ectosone}, Luxiq, Maxivate, {Metaderm}, {Novobetamet}, Occlucort, {Prevex}, Teladar, {Topilene}, {Topisone}, Uticort, Valisone, Valnac

budesonide
INHALATION: Pulmicort
NASAL: Rhinocort, Rhinocort Aqua
LONG-ACTING SYSTEMIC: Entocort EC

clobetasol
TOPICAL/LOCAL
{Dermovate}, Embeline E. Temovate

clocortolone
TOPICAL/LOCAL:
Cloderm

cortisone
SHORT-ACTING SYSTEMIC: {Cortone}, Cortone Acetate

desonide
TOPICAL/LOCAL:
DesOwen, Tridesilon

desoximetasone
TOPICAL/LOCAL:
Topicort

dexamethasone
LONG-ACTING SYSTEMIC:
Cortastat, Dalalone, Decadrol, Decadron, Decaject, Deronil, Dexacorten, Dexameth, Dexasone, Dexone, Hexadrol, Primethasone, Solurex
TOPICAL/LOCAL: Aeroseb-Dex, Decadron, Decaspray

diflorasone
TOPICAL/LOCAL: Florone, Maxiflor, Psorcon

flunisolide
INHALATION: AeroBid, {Bronalide}
NASAL: Nasalide, Nasarel, {Rhinalar}

fluocinolone
TOPICAL/LOCAL: Biio-Syn, Derma-Smoothe/FS, Fluocet, {Fluoderm}, {Fluolar}, Fluonid, {Fluonide}, Flurosyn, FS Shampoo, Synalar, {Synamol}, Synemol

fluocinonide
TOPICAL/LOCAL: Fluocin, Licon, {Lidemol}, Lidex, {Lyderm}, {Topsyn}

flurandrenolide
TOPICAL/LOCAL: Cordran, {Drenison}

fluticasone
INHALATION: Flovent
NASAL: Flonase
TOPICAL/LOCAL: Cutivate

halcinonide
TOPICAL/LOCAL: Halog

halobetasol
TOPICAL/LOCAL: Ultravate

hydrocortisone
SHORT-ACTING SYSTEMIC:
A-hydroCort, Cortef, Hydrocortone, Solu-Cortef
TOPICAL/LOCAL: Acticort, Aeroseb-HC, Ala-Cort, Bactine, ETC.

methylprednisolone
INTERMEDIATE-ACTING SYSTEMIC:
A-Methapred, depMedalone, Depo-Medrol, Depoject, Depopred, Duralone, Medralone, Medrol, Solu-Medrol
TOPICAL/LOCAL: Medrol

mometasone
NASAL: Nasonex
TOPICAL/LOCAL: {Elocom}, Elocon

prednicarbate
TOPICAL/LOCAL Dermatop

prednisolone
INTERMEDIATE-ACTING SYSTEMIC: Articulose, Cotolone, Delta-Cortef, Hydeltrasol, Key-Pred, Nor-Pred, OrapredPediapred, Predacort, Predate, Pred-Ject, Prednisol, Prelone

prednisone
INTERMEDIATE-ACTING SYSTEMIC: Cordrol, Deltasone, Liquid Pred, Meticorten, Orasone, Panasol-S, Pred-Pak, Prednicen-M, Prednicot, Sterapred

triamcinolone
INHALATION: Azmacort, Azmacort HFA
NASAL: Nasacort, Nasacort AQ, Tri-Nasal
INTERMEDIATE-ACTING SYSTEMIC: Amcort, Aristocort, Aristospan, Atolone, Clinacort, Kenacort, Kenaject, Kenalog, Tac, Triam-A, Triam Forte, Triamolone, Triamonide, Tri-Kort, Trilog, Trilone, Tristoject
TOPICAL-LOCAL: Aristocort, Delta-Tritex, Flutex, Kenalog, Kenonel, {Triaderm}, {Trianide}

Front 24

Name 1 leukotriene receptor antagonist?

Back 24

zafirlukast Accolate

Front 25

Name 2 mast cell stabilizers?

Back 25

cromolyn Intal, NasalCrom, {Rynacrom}

nedocromil Tilade