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ACETAMINOPHEN
Classification
Nonopioid analgesic
ACETAMINOPHEN
Action
-Acts as antipyretic by inhibiting prostaglandins in HYPOTHALAMUS
-May block pain impulses peripherally by blocking prostaglandin synthesis
*weak ANTIINFLAMMATORY
ACETAMINOPHEN
Uses
-Mild to moderate pain
-Fever
-Preferred treatment for flu symptoms in children & teens
(arthralgia, dental pain, dysmenorrhea, headache, myalgia, osteoarthritis)
ACETAMINOPHEN
Trade Name
Tylenol
ACETAMINOPHEN
Contraindications
-HYPERSENSITIVITY
-INTOLERANCE TO ALCOHOL, ANY PRODUCT INGREDIENTS
-alcoholism
-kidney/liver disease
-anemia
-geriatric
-breastfeeding
-G6PD deficiency
ACETAMINOPHEN
Adverse Effects
COMMON:
-Stimulation or drowsiness
-Nausea, vomiting, abdominal pain
-Rash, Urticaria
LIFE-THREATENING:
-HEPATOTOXICITY, HEPATIC SEIZURE (from overdose)
-RENAL FAILURE (from high, prolonged doses)
-LEUKOPENIA, NEUTROPENIA, HEMOLYTIC ANEMIA (from long-term use), THOMBOCYTOPENIA, PANCYTOPENIA
-HYPERSENSIVITY
ACETAMINOPHEN
Special Considerations
LIVER TOXICITY AT LOW DOSES
.Daily dose max = 4g
.Acute & long-term use toxicity possible
ACETAMINOPHEN
Interactions
(individual drugs)
Alcohol, carbamazepine, diflunisal, isoniazid, rifabutin, rifampin, sulfinpyrazone: ^ hepatotoxicity, v effect
Ba