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7 Cards in this Set
- Front
- Back
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LSD
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LSD and other psychedlic drugs probably act at 5HT2A receptors
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Psilocybin
Dimethyltryptamine (DMT) |
Psychedlic substituted tryptamines
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Mescaline
MDA Ecstasy (MDMA) |
MDMA has neurotoxicity to 5HT neurons
Methamphetamine is well known dopamine neurotoxin |
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Phencyclidine (PCP)
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Dreamy tanquility with heightened emotional response to stimuli WITHOUT hallucination.
Mechanism: non-competitive NMDA antagonist, also DA and sigma opiate receptor agonist Side Effect: many violent experiences with murder and self mutilation. |
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THC
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Mechanism: CB1 receptors in forebrain dopamine areas
Clinical Use: Lower intraocular pressure in glaucoma and a powerful antiemetic. Side Effects: Tolerance develops with chronic use. Addictive. |
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Cocaine
Amphetamine Methamphetamine |
CNS stimulants
Mechanism: Amphetamine- releases dopamine and blocks reuptake, Cocaine- blocks dopamine reuptake Addiction Treatment: dopamin agonists, TCAs, and opiate antagonists Clinical Use: Amphetamines for narcolepsy Side Effects: MA neurotoxic to dopamine neurons. Spaced admin. -> sensitization and Rapid, repetitive -> tolerance |
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Gamma-butyrolactone
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Strength enhancers, remove inhibitions, "date rape"
May have own specific receptors |
