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11 Cards in this Set

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tetracycline MOA
bacteriostatic; binds to 30s ribosomal subunit and prevents access of aminoacyl tRNA to its acceptor site on the mRNA;
tetracycline use
Vibrio cholerae, Acne, Chlamydia, Ureaplasma, Urealyticum, Mycoplasma pneumonia, Tularemia, H. Pylori, Borrelia burgdoferi (lyme ds.), Rickettsia (rocky mtn spotted fever)
tetracycline SE
GI irritation, tooth discoloration (brown spots) in kids less than 7yo; fatty liver in pregnars;
tetraycline contraindications
pregnars, nursing moms, kids younger than 7yo
drugs in the tetracylcine family
minocycline, (causes vestibular tox)
demeclocycline (used for SIADH)
chloramphenicol MOA
binds to 50s subunit of bac ribosomes; blocks peptidyl transferase (the incorporation of new amino acids into growing strand); bacteriostatic; also inhibits mito-c. protein synthesis in bone marrow cells: causes bone marrow suppression but not aplastic anemia
chloramphenicol clinical use
DOC for meningococcal infections, pneumococcal, and H. flu meningitis in people intolerant of beta lactams
chloramphenicol SE
bone marrow suppression; aplastic anemia; gray baby syndrome (fatal tox in neonates - immature liver unable to metabolize the drug and poor renal tubular secretion); N/V/dia.
the tetracycline group members
+ more;
they are protein synthesis inhibitors
tetracycline contraindications
Must NOT take w/ milk, antacids, or iron-containing preparations b/c divalent cations in the gut inhibit its absorption
Demeclocycline use
ADH antagonist, acts as a D iuretic in SIADH