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11 Cards in this Set
- Front
- Back
- 3rd side (hint)
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tetracycline MOA
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bacteriostatic; binds to 30s ribosomal subunit and prevents access of aminoacyl tRNA to its acceptor site on the mRNA;
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tetracycline use
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VACUUM THe BedRoom
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Vibrio cholerae, Acne, Chlamydia, Ureaplasma, Urealyticum, Mycoplasma pneumonia, Tularemia, H. Pylori, Borrelia burgdoferi (lyme ds.), Rickettsia (rocky mtn spotted fever)
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tetracycline SE
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GI irritation, tooth discoloration (brown spots) in kids less than 7yo; fatty liver in pregnars;
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tetraycline contraindications
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pregnars, nursing moms, kids younger than 7yo
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drugs in the tetracylcine family
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doxycycline,
tetracycline, minocycline, (causes vestibular tox) demeclocycline (used for SIADH) |
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chloramphenicol MOA
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binds to 50s subunit of bac ribosomes; blocks peptidyl transferase (the incorporation of new amino acids into growing strand); bacteriostatic; also inhibits mito-c. protein synthesis in bone marrow cells: causes bone marrow suppression but not aplastic anemia
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chloramphenicol clinical use
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DOC for meningococcal infections, pneumococcal, and H. flu meningitis in people intolerant of beta lactams
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chloramphenicol SE
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bone marrow suppression; aplastic anemia; gray baby syndrome (fatal tox in neonates - immature liver unable to metabolize the drug and poor renal tubular secretion); N/V/dia.
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the tetracycline group members
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doxycycline,
tetracycline, tigecycline + more; they are protein synthesis inhibitors |
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tetracycline contraindications
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Must NOT take w/ milk, antacids, or iron-containing preparations b/c divalent cations in the gut inhibit its absorption
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Demeclocycline use
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ADH antagonist, acts as a D iuretic in SIADH
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