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18 Cards in this Set
- Front
- Back
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Anabolic effects of testosterone
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increased muscle size and strength, bone growth, red cell maturation, erythropeitin production, and decreased HDL
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Methyltestosterone administration
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oral
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Testosterone administration
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transdermal
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Testosterone esters administration
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intramuscularly
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Dihydrotestosterone
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the more active form of testosterone
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Adverse reactions
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Masculinization, growth disturbance, edema, decreased spermatogenesis, feminization, behavioral changes (depression when stopped), tendon rupture, increased serum PSA
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Drug interactions with testosterone
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increased bleeding if on warfarin, decreased metabolism of oral hypoglycemics, echinacea may increase risk of hepatotoxicity
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Uses for testosterone
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hypogonadism, stimulation of growth, reverse protein loss after trauma, surgery, or prolonged immobilization, and, endometriosis (Danazol), women with hypoactive sexual drive, carcinoma of the breast
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Cyproterone, Flutamide, Bicalutamide, Nilutamide, Spironolactone
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androgen receptor antagoists
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Cyproterone, Flutamide, Bicalutamide, Nilutamide, Spironolactone uses
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hirsutism in women, excessive sexual drive in men, and prostate cancer
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Which drug has a Black Box warning for interstitial pneumonitis?
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Nilutamide
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Which drug causes gynecomastia and mild hepatotoxicity (reversible)
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Flutamide
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Finasteride, Dutasteride
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reductase inhibitors, inhibit 5 alpha-reductase so have decreased conversion of testosterone to dihydrotestosterone
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Finasteride, Dutasteride uses
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treatment of BPH, finasteride can be used for male pattern baldness
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Finasteride, Dutasteride side effects
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decreased libido and impotence
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Ketoconazole
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antifungal used to prevent hisutism in PCOD but has toxicity limits
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Leuprolide
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GnRH analog used in treatment of prostate cancer
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Terazosin
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alpha 1a receptor anatgonist for BPH
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