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28 Cards in this Set
- Front
- Back
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One treatment of GERD is to promote motility, what does this mean?
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move contents faster through GI tract
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What is the MOA of motility agents?
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move contents faster through GI, and reduce gastric emptying time
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What are drug of therapy for GERD was removed from the market?
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cisapride
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Why was cisapride (GERD treatment) removed from the market?
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causes serious arrhythmia
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What is the drug of therapy for GERD?
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metaclopramide
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What is the MOA of metaclopramide?
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accelerates gastric emptying
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what are adverse reactions to using motility agents?
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Diarrhea --not enough time for large intestine to absorb H2O/electrolytes.
cisapride removed --arrythmias |
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What is the MOA for proton pump inhibitors (used to treat GERD & PUD)?
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inhibits H+/K+ ATPase pump on parietal cells responsible for pumping HCL into stomach.
Causes potent reduction of secretion |
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What are the names of proton pump inhibitor drugs?
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omeprazole (prototype drug)
esomeprazole Lansoprazole rabeprazole pantoprazole (avail IV) |
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Describe the adverse effects of proton pump inhibitors
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well-tolerated
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What is the MOA for H2 receptor antagonist (treatment of GERD & PUD)?
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binds to Histamine-2 receptors on parietal cells to reduce secretion
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What are the names of drugs for H2 antagonists?
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-cimetidine
-ranitidine -nizatidine -fomatodine |
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describe the adverse effects associated with H2 receptor antagonists.
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generally well-tolerated
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What is the MOA for antacids (treatment of GERD & PUD)?
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basic compound that neutralizes stomach acid to form inert cells
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What are the antacid drugs used?
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Too numerous to count (TNTC)
Malox/Mylanta |
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Because Peptic Ulcer Disease (PUD) is due to incr acidity in stomach or duodenum what classes of drugs can treat his problem?
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Proton Pump Inhibitors
H2 Receptor Antagonists Antacids |
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To eliminate H. Pylori in PUD disease what class of drugs should one use?
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antibiotics
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what is the drug of choice to treat peptic ulcers?
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proton pump inhibitors
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drug ending in "-prazole" is this type of drug
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proton pump inhibitor
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drugs ending in "-tidine" is this type of drug
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H2 receptor antagonists
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what are the adverse effects associated with antacids?
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diarrhea or constipation (depending on agent)
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what is the MOA of antibiotics?
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erradicate microorganism
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Name the antibiotics that are targeted to treat H. Pylori
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metronidazole, clathromycin, amoxicillin, tetracyclin
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common adverse effects associated with antibiotics (PUD treatment)
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allergic, GI distress
Tetracycline -- stain teeth/bones metronidazole- can cause disfulfiram-like rxn if ingested with alcohol |
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5 -aminosalicylic acid derivatives are used to treat...
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Inflammatory Bowel disease (IBD)
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Examples of 5-aminosalicylic acid drugs are:
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sulfasalzine
mesalamine olsalazine basalazide |
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adverse effects for 5-aminosalicyclic acid drugs are:
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GI complaints
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the MOA for 5-aminosalicyclic acid drugs (IBD):
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local anti-inflammatory actions in intestinal tract
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