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40 Cards in this Set

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Name some cholinesterase inhibitors(reversible)
Physostigmine
Neopstigmine
Pyidostigmine
Edrophonium
Carbaryl
Donespexil
Galantamine
Rivastigmine
Cholinesterase Inhibitors(Irreversible Organophosphates)
Echothiophate, Parathion, malathion, chlorpyrifos, VX, Sarin
What symptoms do cholinergic agonists treat?
GI Atony

Non-Obstructive Urinary Bladder Atony

Ophthalmic Disorders(gluacoma)

Myasthenia Gravis

Alzheimers Disease

Xerostomia(dry mouth)
Cholinergic agoinists treat emergencies like?
Supraventicular Tachycardia

Antimuscarinic induced ophthalmic disorders

Reversal of effects of non depolarizing neuromuscular blocking druges.
What is Ach a transmitter of
Postsynaptic PNS Neurons
M1
Neural CNS and Ganglia
Decrease IP3 and DAG
Modifies Neurotransmission
M2
SA and AV nodes
Increase K, decrease cAMP
Slow Heart Rate
M3
Glandular
Decrease IP3 and DAG
Contraction of smooth muscle and secretions of glands
Are muscarinic agonists selective?
No
Which is less susceptable to Ache breakdown?
Carbachol
Which is selective only for GUt an Bladder?
Bethanechol
Pilocarpine
Muscarinic agonist. Tertiary N. Penetrates membranes. eye topical
Miotic
Pilocarpine and carbachol
Myiadratic
atropine
Postoperative abdominal distension
Bethanechol
Urinary Retention
Bethanechol
Diagnosis of bronchial asthma
Methacholine Aerosol
Xerostomia(SjOgrens Syndrome)
Pilocarpine
and
Cevimeline
Toxicity Musc agonists
Syncope
Flushing
MI
Salivation lacrimation
GI
Asthma
Miosis
Acetylchoinesterase(ACHE, TRUE)
Neurons.skeletal muscles.rbc.hydrolizes ach and methacholine.
Butyrylcholinesterase(Psuedo)
Plasma.neuroglia.GI.Inhibition NOT correlated with cholinergic effect.Broader substrate specificity then AChE.
Inhibitors of cholinesterases
Edrophonium
Carbamate inhibitors
Galantamine
Edrophonium
IV only.Reversible binding to ACHE.rapidly excreted by kidneys
NEOSTIGMINE
Carbamate inhibitor
Charged.oral.nocns.
tie up enzyme.quatrinaryN
REVERSIBLE
Physostigmine
Carbamate inhibitor
Old.notcharged.gets to cns.
tie up enzyme.react slowly with water.tertiaryN.REVERSIBLE
Pyridostigmine
Carbamate inhibitor
quatranary N.longer action.myashtenai gravis.
REVERSIBLE
Carbyl
Carbamate inhibitor.head lice
REVERSIBLE
Galantamine,Revastigmine,Donepezil
Alzheimers.not prevenitive.long acting.penetrat bbb
REVERSIBLE
Reversible AcHE Inhibitors
Edrophonium

Neostigmine, Physostigmine, Carbaryl, Pyrostigmine

Galantamine
Esters of Phosphoric acid(organophosphates)
Irreversible inhibitors.
Covalent bond
Uses of Irr inhibitors
Meds
Incecticide
Headlice
Nerve Gas
Treat ACh toxicity
Atropine
Pralidoxime.NMJ.No bbb
Artificial respiration.
Neostigmine
Gluacoma
Atony of smooth msucle of gut and bladder
Neostigmine
Glaucoma
Neostigmine, echothiophate
Myasthenia gravis
Neostigmine, Pyridostigmine, Edrophonium.
Antidiote for curare
Edrophonium, neostigmine
Overdose of muscarinic agonists
atropine, tricyclic antidepressents
Alzehiemers
donepezil, galantamine, recastigmine
Nodal tachycardia and paroxysmal atrial
Edrophonium