Dr. Moore

Front 1

Name some cholinesterase inhibitors(reversible)

Back 1

Physostigmine
Neopstigmine
Pyidostigmine
Edrophonium
Carbaryl
Donespexil
Galantamine
Rivastigmine

Front 2

Cholinesterase Inhibitors(Irreversible Organophosphates)

Back 2

Echothiophate, Parathion, malathion, chlorpyrifos, VX, Sarin

Front 3

What symptoms do cholinergic agonists treat?

Back 3

GI Atony

Non-Obstructive Urinary Bladder Atony

Ophthalmic Disorders(gluacoma)

Myasthenia Gravis

Alzheimers Disease

Xerostomia(dry mouth)

Front 4

Cholinergic agoinists treat emergencies like?

Back 4

Supraventicular Tachycardia

Antimuscarinic induced ophthalmic disorders

Reversal of effects of non depolarizing neuromuscular blocking druges.

Front 5

What is Ach a transmitter of

Back 5

Postsynaptic PNS Neurons

Front 6

M1

Back 6

Neural CNS and Ganglia
Decrease IP3 and DAG
Modifies Neurotransmission

Front 7

M2

Back 7

SA and AV nodes
Increase K, decrease cAMP
Slow Heart Rate

Front 8

M3

Back 8

Glandular
Decrease IP3 and DAG
Contraction of smooth muscle and secretions of glands

Front 9

Are muscarinic agonists selective?

Back 9

No

Front 10

Which is less susceptable to Ache breakdown?

Back 10

Carbachol

Front 11

Which is selective only for GUt an Bladder?

Back 11

Bethanechol

Front 12

Pilocarpine

Back 12

Muscarinic agonist. Tertiary N. Penetrates membranes. eye topical

Front 13

Miotic

Back 13

Pilocarpine and carbachol

Front 14

Myiadratic

Back 14

atropine

Front 15

Postoperative abdominal distension

Back 15

Bethanechol

Front 16

Urinary Retention

Back 16

Bethanechol

Front 17

Diagnosis of bronchial asthma

Back 17

Methacholine Aerosol

Front 18

Xerostomia(SjOgrens Syndrome)

Back 18

Pilocarpine
and
Cevimeline

Front 19

Toxicity Musc agonists

Back 19

Syncope
Flushing
MI
Salivation lacrimation
GI
Asthma
Miosis

Front 20

Acetylchoinesterase(ACHE, TRUE)

Back 20

Neurons.skeletal muscles.rbc.hydrolizes ach and methacholine.

Front 21

Butyrylcholinesterase(Psuedo)

Back 21

Plasma.neuroglia.GI.Inhibition NOT correlated with cholinergic effect.Broader substrate specificity then AChE.

Front 22

Inhibitors of cholinesterases

Back 22

Edrophonium
Carbamate inhibitors
Galantamine

Front 23

Edrophonium

Back 23

IV only.Reversible binding to ACHE.rapidly excreted by kidneys

Front 24

NEOSTIGMINE

Back 24

Carbamate inhibitor
Charged.oral.nocns.
tie up enzyme.quatrinaryN
REVERSIBLE

Front 25

Physostigmine

Back 25

Carbamate inhibitor
Old.notcharged.gets to cns.
tie up enzyme.react slowly with water.tertiaryN.REVERSIBLE

Front 26

Pyridostigmine

Back 26

Carbamate inhibitor
quatranary N.longer action.myashtenai gravis.
REVERSIBLE

Front 27

Carbyl

Back 27

Carbamate inhibitor.head lice
REVERSIBLE

Front 28

Galantamine,Revastigmine,Donepezil

Back 28

Alzheimers.not prevenitive.long acting.penetrat bbb
REVERSIBLE

Front 29

Reversible AcHE Inhibitors

Back 29

Edrophonium

Neostigmine, Physostigmine, Carbaryl, Pyrostigmine

Galantamine

Front 30

Esters of Phosphoric acid(organophosphates)

Back 30

Irreversible inhibitors.
Covalent bond

Front 31

Uses of Irr inhibitors

Back 31

Meds
Incecticide
Headlice
Nerve Gas

Front 32

Treat ACh toxicity

Back 32

Atropine
Pralidoxime.NMJ.No bbb
Artificial respiration.

Front 33

Neostigmine

Back 33

Gluacoma

Front 34

Atony of smooth msucle of gut and bladder

Back 34

Neostigmine

Front 35

Glaucoma

Back 35

Neostigmine, echothiophate

Front 36

Myasthenia gravis

Back 36

Neostigmine, Pyridostigmine, Edrophonium.

Front 37

Antidiote for curare

Back 37

Edrophonium, neostigmine

Front 38

Overdose of muscarinic agonists

Back 38

atropine, tricyclic antidepressents

Front 39

Alzehiemers

Back 39

donepezil, galantamine, recastigmine

Front 40

Nodal tachycardia and paroxysmal atrial

Back 40

Edrophonium