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37 Cards in this Set
- Front
- Back
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What virus falls in the family Papovirade has dsDNA and is not enveloped and causes warts? |
HPV |
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What can HPV cause? |
1.Benign warts 2.Condyloma acuminata 3.Cervical cancer 4. Other cancers. (vulva, vagina, penis, anus) 5. Cancer in the back of the throat |
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What seroytpes of HPV are the main cause of genital warts in people age 17-33 and are generally acquired through sex? |
HPV 6 and 11 |
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What serotypes can cause cervical cancer? |
HPV 16 mainly, 18, 31 and 45 |
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How does HPV take over the cell genome? |
Integrates into host genome and cell cycle control is disrupted |
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How can we diagnose Warts? |
1.Visually 2.Use vinegar. Turns areas with HPV white
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What can pap smears reveal? |
Koilocytic squamous epi. cells(Vacuolated cytoplasm). IF paps smear is inconclusive we follow up with HPV DNA test |
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What test detects a cocktail of 13 different types of oncogenic HPV and reports results as positives for one or more or negative for all? |
Hybrid capture (HC2) |
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WHat test detects HPV 66 in addiction to the 13 types detected by HC2? |
Cervista NOTE: THis test also indicates positivity for one or more types in the 14 probe mix, but also offers the option of testing for HPV 16/18 specifically |
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WHAt test uses a probe mix to detect HPV 16 and 18 while detecting the remaining 12 types? |
PCR cobas |
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WHat is the protocol for paps smears that show Atypical or low grade oncogenic cells? |
Redo pap test 3-6 months. If second pap is abnormal, she would undergo a colposcopy and biopsy |
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WHat test can be used to further evaluate those with ASCUS paps? |
HPV DNA allows to seperate those with high risk HPV and low risk HPV |
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Can genital warts be dangerous? |
YEs if undetected it can be life threatening and lead to oncogenic transformations |
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What two types are the main cause of Cervical cancers? |
16 and 18 |
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What type causes anal cancer? |
16
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What types cause vaginal, vulvar, and penile cancers> |
16 and 18 |
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What type causes cancer in the oropharynx? |
16 |
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What factors increase the risk of developing cancer following a high risk HPV infection? |
1. Smoking 2.Weak immune 3.Having many children( esp. cervical) 4.Long term oral contraceptive use (esp. CErvical 5.Poor oral hygiene (esp. oropharynx 6. Chronic inflamation |
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Can I infect others? |
yes. Asymptomatic shedding |
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What can it be transmitted> |
1.Direct contact 2.Autoinoculation 3. fomite. even chlorinated pools |
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Can HPV be transmitted to a child during vaginal delivery? |
Rarely. IF it happens its seen on babys genitals or upper respiratory system |
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Can HPV infections go undetected? |
Yes, because they don't always cause warts |
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Who is at higher risk for infection? |
Sexually active people and children |
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What are the two vaccines Against HPV? |
Gardasil and Cervarix |
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What serotype do they target? |
16 and 18 |
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Besides targetting 16 and 18, what other two serotypes does gardasil target? |
6 and 11 |
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How does the vaccine prevent infection? |
Elicit virus-neutralizing abs. that prevent initial infection with the types in the vaccine |
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Gardasil is usually recommended for what age group? |
11 and 12 years of age. But it can also be given to women 13-26 years of age |
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How many injections are given for gardasil? |
series of 3 injections. @ 0-2-6 months |
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Cervarix is usually recommended for what age group? |
girls 10-25 |
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How many injections are given for cervarix? |
series of 3 @ 0-1-6months |
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T/F According to a new study. One dose of cervarix can provide enough immune response to protect women from HPV 16 and 18 |
True |
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Can males also get vaccinated? |
Yes, Gardasil between ages 9 to 26 |
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What are some of the main adverse effect of gardasil vaccination? |
1.Syncope(fainting) 2.Guillian Barre syndrome 3.Blood clots
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Who is at higher risk of blood clots post gardasil vaccination? |
Women taking oral contraceptives, smokers, obese |
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What is the treatment for Cervical cancer? |
Surgery Radiation therapy Chemo RT and chemo A combination of all three methods |
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How do you manage HSIL? |
Colposcopy and biopsy |
