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22 Cards in this Set
- Front
- Back
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Levothyroxine
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T4
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Liothyronine
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T3
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Why is Levothyroxine preferred over liothyronine?
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T4 has a longer half life and T4 will be converted into T3
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Levothyroxine and liothyronine clinical use
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hypothyroidism, TSH suppression therapy in patients with thyroid cancer, occasionally a nontoxic goiter
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Levothyroxine or liothyronine for myxedema coma?
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liothyronine maybe because it has a faster onset
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Propanolol
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beta blocker used in Grave's disease and thyroid storm
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Thiamide drugs MOA
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inhibit the synthesis of TH by inhibiting thyroid peroxidase
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Iodide salts MOA
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inhibit the synthesis and release of TH
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Radioactive iodine MOA
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destroys thyroid tissue
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Methimazole
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thioamide
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Propylthiouracil
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thioamde
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Propylthiouracil MOA
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inhibits thyroid hormone deiodinase (the conversion of T4 to the active form T3)
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Thioamides adverse effects
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skin rash, pruritus, fever, agranulocytosis
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Methimazole side effec
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teratogenic likely in the first trimester
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Propylthiouracil side effects
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hepatotoxicity and liver failure
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Which thioamide is the first line treatment for hyperthyroidism?
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Methimazole
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How do you treat a pregnant patient with hyperthryoidism?
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1st triemster is Propylthiouracil and then Methimazole for the 2nd and 3rd
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Biggest side effect of radioactive iodine is
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hypothryoidism because it destroys thyroid tissue
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Absolute contraindications for radioactive iodine
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pregnancy, lactation, and inability to comply with radiation safety regulations
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When to use iodide salts
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preoperatively, adjunct to methimazole for Grave's disease, and adjunct for radioacive iodine (after radioactive iodine)
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Drugs for a thyroid storm
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Propanolol, Methimazole, Iodide salts, Propylthiouracil (Iodid salts are given at least an hour after a thioamide)
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3 situations to use propylthiouracil over methimazole
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1st trimester, allergic reaction to Methimazole (withou agranulocytoiss), and thyroid storm
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