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23 Cards in this Set
- Front
- Back
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Enoxaparin
Dalteparin Tinzaparin |
Low Molecular Weight Heparin
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UFH, MOA
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Binds thrombin to anti-thrombin
Binds anti-thrombin to factor Xa |
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LMWH, MOA
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Binds anti-thrombin to factor Xa
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UFH pharmacokinetics
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IV
Unpredictable Monitor via aPTT |
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LMWH pharmacokinetics
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Sub Q
Predictable No monitoring needed (unless pregnant) Can be used at home Expensive |
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Heparin clinical use
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PE
DVT STEMI!!!! NSTEMI UA Post op (prevent DVT) PCI Afib Pregnancy |
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Fondaparinux
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Sub Q
Factor Xa inhibitor |
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Fondaparinux clinical use
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Prophylaxis of DVT
Acute PE and DVT (with warfarin) UA NSTEMI STEMI |
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Lepirudin
Bivalirudin |
Thrombin inhibitors
IV |
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Dabigatran
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Thrombin inhibitor
Oral |
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Thrombin inhibitors clinical use
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HIT (Lepirudin)
PCI(Bivalirudin) Prophylaxis of DVT(Desirudin) Nonvalvular Afib(Dabigatran) |
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Warfarin clinical use
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Chronic Afib
Prosthetic heart valve poast surgery, trauma, or cancer DVT PE STEMI |
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Warfarin side effects
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Purple toes
Tissue necrosis Teratogenic Venous limb gangrene (if used when pt. has HIT) |
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Cox-1 inhibitor (antiplatelet)
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Aspirin
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Aspirin MOA
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Irreversibly inhibits Cox 1 and 2
blocks the production of TxA2 |
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Aspirin clinicl use
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STEMI
NSTEMI UA PCI Embolic Stroke |
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Clopidogrel
Prasugrel |
Oral
ADP Receptor Antagonists |
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Abciximab
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IV
GP IIb/IIIa Receptor Antagonists |
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Clopidogrel clinical use
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similar to aspirin
MI PCI given with aspirin |
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Abciximab clinical use
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PCI
UA NSTEMI given with aspirin and Clopidogrel |
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Streptokinase
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thrombolytic
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Alteplase
Reteplase Tenecteplase |
Thrombolytics
Recombinant t-PA |
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Thrombolytics clinical use
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STEMI
DVT PE NOT for NSTEMI or UA |
