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22 Cards in this Set
- Front
- Back
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What happens if block voltag-gated sodium channels from the outside?
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increasing paralysis (puffer fish)
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What happens if block voltage-gaed potassium channel?
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muscle paralysis (scorpion)
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What happens if block ligand-gated nicotinic acetylsholine receptor at NMJ?
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increased muscl relaxation/paralysis (south american plant, poison arrow tips)
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What happens if have a competitve antagonist for the ligand-gated glycine receptor?
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muscle spasms (strychnine)
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Major exitatory AA NT
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Glutamate
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Main glutamate receptor
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NMDA
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How does the NMDA receptor work?
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Glutamate binds and then NMDA allows influx of ions (Na, Ca)
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What is excitotoxicity?
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Too much glutamate in the synapse leads to too much Ca influx which leads to neuronal death
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Main inhibitory AA NT
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GABA
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How is GABA inhibitory?
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It is selectively permeable to Cl-
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Is GABAa fast or slow?
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fast
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What type of meds use GABAa?
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Seziure meds
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What mediates acetycholine actions?
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GPCR muscarinic receptors
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Gq
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increased IP3 and DAG
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Gi
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decreased adenylyl cyclase and cAMP
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What disease is mediated by acetylcholine levels?
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Alzheimers
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What is the major catecholamine NT?
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dopamine
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What NT are G protein coupled?
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Acetylcholine and dopamine
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Metabotropic receptors for dopamine
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D1-D5
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D1 and D5
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Gs, increase cAMP
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D2, D3, D4
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Gi, decreases cAMP
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What type of drugs pass the BBB?
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lipophilic
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