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13 Cards in this Set
- Front
- Back
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What 4 sub-classes of ABX falls under PCN
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1. Natural PCN
2. Methicillin 3. Amox (Aminopenicillin) 4. Piperacillin |
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What are the natural penicillins (PCN)?
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Pen G (IV)
Pen VK (PO) Bicillin CR (benzathine/procaine) Bicillin LA (benzathine) |
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What are the classification of natural PCN?
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beta-lactam
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Which organism does natural PCN treat?
Hint: 6 bugs |
STREP
- pneumo: PCN-sen meningitis - pyogenes: cellulitis, myositis, fasciitis, Erysipelas - bovis: pharyngitis - viridans: endocarditis Spirochetes (Treponema pallidum): syphilis C. perfringens: gangrene |
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What is the MC ADR of natural PCN?
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hypersensitivity
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What are the methicillins?
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Oxa- (IV), Naf- (IV): 1-2g q4hr
Cloxa- (PO), Dicloxa- (PO): 500mg q6hr |
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Why are methicillin used? (i.e. what indication?)
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PCN-resistant penicillins (i.e. in penicillin-resistent strep) and STAPH infection.
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What organism does Methicillin treat?
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Streptococci (pcn-resistant)
Straphylococci |
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What are the common staph infections?
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1. Cellulitis (alt: vanc, clinda)
2. Endocarditis (IV user): Naf + Gent 3. Osteomyelitis: Naf (Vanc to cover S. epi in artificial joints 4. Septic arthritis 5. Meningitis 6. Impetigo (alt: bactroban) |
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What is the clearing-mechanism of the methicillins?
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Naf: biliary (no renal adj needed)
Oxa/Diclox: biliary and renal |
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What are the ADR of Naf and Oxa?
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Naf: neutropenia
Oxa: hepatotoxicity |
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What are the Aminopenicillins?
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Ampicillins
- 1-2g q6hr (IV) - 250-500mg q6hr (PO) Amox - 250mg-1g TID (PO) Augmentin (Amox/Clavulanic) - 500/125 TID (PO) - 875/123 BID (PO) |
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What organism does Amox treat?
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Streptococci
Enterococcus Listeria monocytogenes E. coli (30% resist) Hemophilus (30% resist) |
