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30 Cards in this Set
- Front
- Back
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Which of the following statements describes a surfactant?
a. Accumulates at the interface of two liquids and increases interfacial tension. b. Adheres to surfaces and prevents wetting. c. Accumulates on a liquid surface and decreases surface tension. d. Allows the dissolution of an immiscible organic solvent in water. |
c. Accumulates on a liquid surface and decreases surface tension
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Which of the following solutions is purely aqueous?
a. Syrup b. Elixir c. Tincture d. Spirit |
a. Syrup
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When a solvent, at a given temperature, has dissolved all the solute (drug) it can, it is said to be:
a. Concentrated b. Unsaturated c. Saturated d. Freely soluble |
c. Saturated
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We consider a solution ideal, if it is
a. Concentrated b. Dilute c. Aqueous d. Binary |
c. Aqueous
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Which of the following methods will NOT increase the rate of dissolution?
a. Agitation b. Increasing the viscosity of the solvent c. Decreasing the particle size of the solvent d. None of the above |
b. Increasing the viscosity of the solvent
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Which of the following methods produces the smallest particles to be used in making suspensions?
a. Micropulverization b. Jet-milling c. Spray drying d. Mortar and pestle |
b. Jet-milling
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By increasing the viscosity of the liquid used as the medium of a suspension
a. One can expect a faster rate of settling b. The rate of settling is going to be slower. c. The rate of settling is not affected. d. The wetting of the suspending particles is going to be improved. |
b. The rate of settling is going to be slower.
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In which type of fluids is characterized by NO change in the viscosity as a function of the shearing stress?
a. Plastic b. Pseudo-plastic c. Shear-thinning d. Newtonian |
d. Newtonian
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Ciprofloxacin (an acid drug) would absorb at which pH most effectively?
a. 1 b. 4 c. 7 d. 10 |
d. 10
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Which section of the human GI tract would you expect the greatest fraction of Ciprofloxacin (an acid drug) to be absorbed?
a. Stomach b. Small intestine c. Large intestine d. Liver e. Kidney |
b. Small intestine
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Which of the following dosage forms is not entirely (exclusively) water-based?
a. NaF oral solution b. Iodine tincture c. Cimetidine HCl liquid d. Psuedophedrine syrup |
b. Iodine tincture
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Solubility is defined as a mixture of two or more components forming a homogenous molecular dispersion. It mainly depends on
a. solute and solvent b. temperature c. pH d. All of the above |
d. All of the above
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Solubility is defined as a mixture of two or more components forming a homogenous molecular dispersion. It mainly depends on
a. solute and solvent b. temperature c. pH d. All of the above |
d. All of the above
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Elixirs are:
a. Always medicated b. Clear, sweetened hydroalcohholic solutions for oral use c. Clear, sweetened hydroalcohholic solutions for oral and topical use d. Saturated solutions of volatile oils in water e. Saturated solutions of volatile oils in alcoholic or hydroalcoholic solutions |
b. Clear, sweetened hydroalcohholic solutions for oral use
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The characteristics of a well formulated suspension are:
a. Resuspend easily upon shaking b. Homogenous mix of drug c. Physically and chemically stable during its shelf life d. Sterile e. All of the above f. None of the above g. Only A, B, and C are correct |
e. All of the above
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Which of the following statements regarding the HLB value are true?
a. The HLB value indicates the substance's polarity b. Detergents are surfactants with HLB values of 13-16 c. HLB values are additive d. Surface active agents having an assigned HLB balue of 3-6 are greatly lipophilic and produce O/W emulsions e. Agents with HLB values of about 8 to 18 produce W/O emulsions f. All of the above g. Only A-C h. Only D-E |
g. Only A-C
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Which of the following drug degradation processes may be prevented by the addition of ascorbic acid to the dosage form?
a. Hydrolysis b. Epimerization c. Complex formation d. Oxidation |
d. Oxidation
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Which of the following may generally catalyze hydrolysis in a dosage form?
a. acid b. moisture c. metal ions d. none of the above |
b. moisture
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The temperature dependence of the rate constant of chemical reactions is described by the:
a. Arrhenius equation b. Q10 method c. Stoke's Law d. None of the above |
a. Arrhenius equation
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Which of the following dosage forms would be homogenous?
a. Aromatic water b. Suspension c. Elixirs d. Emulsion e. More than one of the above |
e. More than one of the above
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Which of the following is true for teh hydrophilic-lipophilic (HLB) number?
a. It describes the balance between the water loving and oil loving portions of surfactants b. It has an arbitrary range of 1-40 c. It increases with increasing hydrophilicity d. All of the above |
d. All of the above
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Which route of administration can emulsions be given?
a. Oral b. Topical c. Parental d. All of the above e. None of the above |
d. All of the above
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When comparing solutions to suspensions which of the following statements is/are true?
a. Solutions usually mask taste better than suspensions b. Caking occurs more with suspensions than solutions c. Suspensions are more stable to hydrolytic degradation d. Sweetening agents are added to solutions but not to suspensions e. Placing a suspension in the refrigeration accelerates particle settling |
b. Caking occurs more with suspensions than solutions
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Elixirs
a. Contains ethanol to increase the solubility of hydrophilic drug b. Contains ethanol as a preservative c. Usually contains sugar as viscosity adding agent d. Have a higher tendency to form a crust around the cap of the bottle than syrup e. Contains surfactants to decrease the surface tension between water and ethanol |
a. Contains ethanol to increase the solubility of hydrophilic drug
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Which of the following statements is true for syrups?
a. Diabetic syrups contain aspartame as a viscocity agent b. Most syrups can dissolve carboxylic acids since it has an acidic pH c. Mask taste since the majority of syrups are carbonated d. Are self-preserved if the sucrose concentration is greater than 55% e. More easy to reproduce dose as compared to suspensions |
d. Are self-preserved if the sucrose concentration is greater than 55%
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In the talcum powder (Talc) method of preparing aromatic waters, the purpose of Talc is?
a. Suspending agent b. Increase surface area of oil c. Surfactant d. Viscosity agent e. Preservative |
c. Surfactant
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Which instability is incorrectly matched with its dosage form?
a. Solutions: Hydrolysis b. Emulsions: Creaming c. Suspensions: Caking d. Emulsions: Cracking e. Suspensions: Coalescence |
d. Emulsions: Cracking
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Which of the following would NOT increase the dissolution of a drug that dissolves by an endothermic process?
a. Addition of heat b. Increase in particle size c. Increase the stirring rate d. Decreases the viscosity of the liquid e. Shaking the particles in the liquid |
b. Increase in particle size
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Which one of the ingredients used in formulating an over-the-counter anti-itch oitment is preservative?
a. Methylparaben b. Mineral oil c. Microcrystalline wax d. Cholesterol e. None of the above |
a. Methylparaben
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Which of the following agents can be used to form a barrier around oil droplets in the production on an emulsion that does not reduce surface tension?
a. Acacia b. Triton X-100 c. Sodium Stearate d. White Petroleum e. Mineral Oil |
a. Acacia
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