Dosage Forms 2, Oral Controlled/sustained Released Systems, Final, Test 3

Front 1

some other names for oral dosage forms

Back 1

controlled released

sustained release

prolonged release

timed released

Front 2

non dissolving matrix consists of a drug ----- disperesed.

Back 2

uniformly

Front 3

main type of matrix in nondissolving

Back 3

wax matrix

Front 4

in the wax matrix the portion of the drug intented for sustained release is combined w/ ------ and processed into ---- which are compressed into matrix type tablets

Back 4

lipid (wax)

granules

Front 5

what type of drug uses wax matrix

what's the purpose of using this

Back 5

slow K, Klor Con, other K tabs

since the drug slowly released, less GI irritation

prevents high local conc. of K

Front 6

another med that uses the wax matrix?

why

Back 6

Fe

reduce GI irritation by preventing local conc of K

Front 7

ex of swelling/eroding matrix

Back 7

Geomatrix

Front 8

the layers of the geomatrix

Back 8

drug/matrix

modulating barriers

Front 9

the drug/matrix core ---- and ---- swells over time gradually increasing SA

Back 9

hydrates

swells

Front 10

modulating barriers control the rate of ----- thus modulating the release rate

Back 10

hydration

Front 11

all layers of the geomatrix eventually erode,leaving no ---- residue

Back 11

GI

Front 12

dilacor CR cap contain ----/---- tabs in multiples of 60mg. the CR begins in 1 hr and progresses for 24 hrs

Back 12

swelling/dissolving

Front 13

why are drug particles coated

Back 13

to prolong drug release

Front 14

name some coating particle systems

Back 14

dissolving

nondissolving

combinations

Front 15

this has a coat that slowly dissovles, which allows fluid access to the drug. thereby, controlling drug dissolution

Back 15

dissolving coat system

Front 16

in coated pellets the drug soln is in a ----- ---- solvent is coated in small --- beads made of --- and ------.

Back 16

nonaqueous

inert

sugar

starch

Front 17

the beads are coated w/ a slowly dissolvign material such as -----, -----, or a mix of both

Back 17

wax

polymers

Front 18

the release rate of the dissolving coat system is controlled by ----- ----- and type of ----

Back 18

coating thickness

coat

Front 19

uncoated beads provide the ----- dose

Back 19

initial

Front 20

coating dissolution is proportional to the -----

Back 20

thickness

Front 21

the ---- in thickness endows the product w/ a ----- overall release pattern

Back 21

overlap

steady

a mixture of thickness prolongs the blood levels

Front 22

types of nondissoving

Back 22

microencapsulated crystals

encapsulated particles and granules

Front 23

microencapsulated crystals are ---- crystals encapsulated by --- coating of wall material

Back 23

microscopic

thin

Front 24

microK is a capsule containing KCL microcrystals surrounded by a --- membrane. the microcrystals acta as a --------

Back 24

polymer

microreservoirs

Front 25

water enters the microreservior and slowly dissolves the KCL which slowly diffuse in/out . . . this reduces ----- irritation

Back 25

out

GI

(this is a diffusion device: reservoir)

Front 26

k dur microburst release system is a tablet that (rapidly/slowly) disintegrates into microencapsulated crystals

Back 26

rapidly

(this is a whole bunce of microcrystals compressed together)

Front 27

encapsulated particles and granules such as Micro-K LS is a polymer KCL that not only suppresses GI irritation but renders the suspension ----

Back 27

tasteless

Front 28

toprol is controlled release tab that disintegrates, the pellets released over -- hrs

Back 28

24

Front 29

example of combination dissolving/nondissolving

Back 29

SODAS

CODAS

Front 30

combo are small beads of drug exicipients that are surrounded by layers of ---- and ---- polymers.

Back 30

soluable

insoluable

Front 31

in combo, when in the GI tract the soluble/insoluble polymers dissolve leaving pores w/in the outer membrane. fluid then enters the core of bead and dissolves the drug

Back 31

soluble

Front 32

the cr beads can be ---- in to a tab or filled into a capsule

Back 32

compressed

Front 33

CODAS enable a ---- in the release of the drug

here the drug is matched up w/ the ----- pattern

Back 33

delay

diurnal

Front 34

in CODAS the soluable polymer takes several ----- to dissolve

Back 34

hours

Front 35

ex. verelan pm is used ------ ; the drug is not release until 4-5 hrs after ingestion.

why's this significant

Back 35

chronotherapeutically

this is a Ca channel blocker so when taken at night it works in the morning when there's a higher risk of MI

Front 36

membrane matrix ex

Back 36

IPADS

Front 37

IPADS are tiny beads composed of a ----- of drug surrounded by a ---------semipermeable membrane

Back 37

micromatrix

rate limiting

Front 38

IPADs prevents ---- irritation

Back 38

GI

Front 39

Naproxen/Naprelan has (delayed/immediate) released drug that's blended w/ the IPDAS beads so it's -------

Back 39

immediate

biphasic

has a fast and slow release

Front 40

osmotically controlled is surrounded by a ---- membrane and release governed by ----- -----

Back 40

semipermeable

osmotic pressure

Front 41

two osmotically active compartments

Back 41

osmotic drug core

polymeric push compartment

Front 42

in osmotic drug core water causes formation of a --- ----

Back 42

fine suspension

Front 43

in the push compartment water hydrates a ---- causing it EXPAND which then forces the drug of the the ---- ---- orifice

Back 43

polymer

laser drilled

Front 44

osmotically controlled system is what order

Back 44

nearly zero

Front 45

ex of osmotically controlled system:

Back 45

GITS

Front 46

a variation of GITs is a coating w/ drug in it with another concentration inside.

what's the purpose of this

Back 46

the coating w/ drug in side is for the initial dose

for ascending relief

Front 47

the intervening layer between osmotic shell and inner compartments prevents -- ----- into the core

Back 47

water penetration for 4-5 hrs

Front 48

exx of variation of GITS

Back 48

covera HA enables chronotherapeutic tx: allows drug, after being taken in the PM, to begin working in AM when BP and HR at diurnal peak

Front 49

will GITS end up in the stool

Back 49

yes

Front 50

Ion exchange systems generally utilize ----- which are composed of water - (insoluable/soluable) cross-linked polymers

Back 50

resins

insoluable

Front 51

he polyers in ion exhanges contain --- forming funcitonal groups in repeating positions on a polymer chain

Back 51

salt

Front 52

in ion exchange the drug is bound to a ------- and is released by ----- w/ appropriatedly charged ions in the GI tract

Back 52

resins

exchanging

Front 53

pennkinetic system has a (dissolving/nondissolving) polymer

Back 53

nondissolving

Front 54

the polymer controls the ----- if the GI ions and the --- of the drugs

Back 54

inflow

outflow

Front 55

what are standard enteric coat polymers?

at what pH are they soluable

so where do they dissolve

Back 55

pthalates

more than 5.2

Small Intestine

Front 56

what dissolves at a pH greater than 7?

Back 56

eudragit S

allows release of mesalamine lower in the GI tract, for topical antiinflammatory activity

ex: asacol