Dosage Form Final Review

Front 1

Prepared and formulated like hard candy

Back 1

Lozenges

Front 2

Compressed into a hard disc intended to dissolve slowly

Back 2

Troches

Front 3

Pleasant tasting tablets designed to disintegrate smoothly in the mouth.

Back 3

Chewable tablets

Front 4

Prepared by compressing the drug with effervescent salt mixtures

Back 4

Effervescent tablets

Front 5

tablet that is designed to disintegrate in the mouth before swallowing.

Back 5

Fast-dissolving tablets

Front 6

3 ways fast-dissolving tablets are created

Back 6

1.freeze drying
2.direct compression with special disintegrants
3.molding

Front 7

Solid dosage forms of various weights and shapes usually medicated for insertion into the rectum vagina or the urethra

Back 7

suppositories

Front 8

What makes up a suppository

Back 8

Active ingredient
Additives
Suppository Base

Front 9

List oil-soluble suppository bases

Back 9

cocoa butter
synthetic triglycerides

Front 10

List water soluble/water miscible suppository bases

Back 10

Glycerinated Gelatin
Polyehtylene Glycol (PEG) poylmers

Front 11

Is used to determine how much of a base will be displaced by a drug

Back 11

Density Factor

Front 12

What is the rate limiting step for drugs to cross the skin?

Back 12

Stratum Cornea

Front 13

What are the units for flux?

Back 13

J= accumulation amount/ area*time

J=micromoles/cm2h

Front 14

What are the units for Cv?

Back 14

micromoles/cm3

Front 15

Liquid preparations of topical drug delivery

Back 15

Liniments
Lotions
Paints
Ear drops

Front 16

Other topical drug delivery systems

Back 16

gels
powders
ointments
creams
aerosols
Tapers
Plasters

Front 17

Skin Functions

Back 17

Protective Barrier
Homeostasis
Sensory
Secretory
Excretory

Front 18

Composed of layers of keratinocytes
Provides mechanical protection, prevents fluid loss, and keeps microorganisms form invading the body.

Back 18

Epidermis

Front 19

Epidermal Layer
Kerantinocytes called corneocytes.
Flattened non-nucleated cells filled in with keratin filaments
constantly sloughed off
First line of defense for body

Back 19

Stratum Corneum

Front 20

Epidermal Layer
More common in thick skin
Thin translucent lightly stained layer of non-nucleated cells

Back 20

Stratum Lucidum

Front 21

Epidermal Layer
3-5 lyaers of polygonal cells with central nuclei and many basophilic granules
Contain proteins that bind keratin filaments together.

Back 21

Stratum Granulosum

Front 22

Epidermal Layer
Cuboidal, polygonal or sqamouns cells
Desmosomes: cell to cell adhesion

Back 22

Stratum Spinosum

Front 23

Epidermal Layer
Cuboidal cells attached to basal lamina
Mitotic
single cell layer
Merkel cells and melanocytes

Back 23

Stratum Basale/Germinativum

Front 24

Two layers of the Dermis

Back 24

Papillary Region and Reticular Region

Front 25

Shields exposed skin surface from harmful stimuli

Back 25

Protectives

Front 26

Absorbs moisture form skin and local wound, to discourage bacterial growth

Back 26

Absorbents

Front 27

Can alleviate irritation of mucous membrane

Back 27

Demulcents

Front 28

Fat or oily substances used to increase moisture content of skin

Back 28

Emollients

Front 29

Coagulate blood, help wounds and cuts heal quickly

Back 29

Astringent

Front 30

increase skin temperature by increasing circulation at the surface

Back 30

Rubefacients

Front 31

destroy skin at an applied sites (warts keratoses hyperplastic tissue)

Back 31

Caustics

Front 32

causes peeling of skin, useful in treatment of eczema, acne, etc.

Back 32

Keratdytics

Front 33

Topical Dosage forms ingredients

Back 33

Base or body
Medicinal agent
Preservative

Front 34

Semisolid preparations intended for external uses

Back 34

Ointments

Front 35

Ointment bases

Back 35

Hydrocarbon
Absorption
Emulsion W/o
Emulsion o/w
Water miscible

Front 36

Uses geometric dilution to add powder

Back 36

Levigation

Front 37

Incorporates wax and hard fusible bodies into soft oleaginous materials

Back 37

Fusion

Front 38

Opauque solids or thick liquids intended for external use.

Back 38

Creams

Front 39

Contains a large proportion of solid material than ointment

Back 39

Paste

Front 40

Gel classification
if the gel mass consists of a network of small inorganic discrete particles

Back 40

two-phase system

Front 41

gel classification
if the gel mass consists of a network of large organic particles

Back 41

single-phase system

Front 42

gel classification
contains water as part of base

Back 42

Hydrogel

Front 43

gel classification
contains hydrocarbons as main base

Back 43

Organogel

Front 44

soaking up liquid without a marked increase in volume

Back 44

Imbibition

Front 45

soaking up liquid with an increase in volume

Back 45

swelling

Front 46

gel exudes fluid-causing shrinkage

Back 46

syneresis

Front 47

viscous during storage but loses consistency and become fluid upon shaking

Back 47

Thixotropy

Front 48

liquid is removed form a gel, only the framework remains

Back 48

xerogel

Front 49

Gelling Agents

Back 49

Alginic Acid
Carbomer
Cellulose Derviatives-CMC
Gum Arabic
Gelatine
Plastibase
Poloxamers

Front 50

alcoholic vehicle

Back 50

tincture

Front 51

Outer Ear

Back 51

Pinna/auricle
External Auditory Canal

Front 52

Middle Ear

Back 52

3 ossicles
opening of eustachian tube

Front 53

Inner Ear

Back 53

Receptors for hearing and balance
Vestibules
Semicircular Canals

Front 54

An infection of the middle ear that is common in young children
Fluid builds up in middle ear

Back 54

Otitis Media

Front 55

Common in people who swim frequently or get the insides of their ears wet during showering or bathing
an infection of the lining of the external auditory canal.

Back 55

Otitis Externa

Front 56

Causes dizziness, ringing in the ear temporary hearing loss, and a felling of pressure or fullness in the ear.
No cure

Back 56

Meniere's disease

Front 57

Occurs when something prevents sound waves from reaching the receptors in the cochlea

Back 57

Conductive Hearing Loss

Front 58

Occurs when the receptors are unable to receive stimuli or transmit nerve impulses

Back 58

Sensorineural Hearing Loss

Front 59

Lining of the cheek (usually btwn the check and gum)

Back 59

Buccal

Front 60

Ventral surface of the tongue and floor of mouth

Back 60

Sublingual