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10 Cards in this Set
- Front
- Back
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Class |
Sympathomimetic; vasopressor |
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Mech |
Dopamine stimulates alpha beta1 and dopaminergic receptors. Acts indirectly by causing release of norepi from storage sites in sympathetic nerve endings. The effects of dopamine are dose related. At low doses b1 and dopaminergic receptors are simulated. At high doses alpha effects predominate |
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Onset |
IV drip has rapid onset and lasts as long as drug is being infused |
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Indications |
Symptomatic hypotension. With exception of cardiogenic shock, fluid resuscitation must be attempted before dopamine
Symptomatic bradycardia refractory to atropine |
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Contra |
Shock in the setting of trauma
Uncorrectd tachydysrhythmias except sinus tach
Pheochromocytoma |
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Precautions |
Extravasation causes tissue necrosis |
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Side effects |
Increased myocardial demand. Ischemia. Tachydysrhythmias |
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Interactions |
Sodium bicarb can deactivate catecholamines. MAO inhibitors potentiate the effects |
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Dosage |
5-20 mcg/kg/minute IV infusion
Improve cardiac output (beta) 5-10mcg/kg/min
Increase peripheral basically resistance (alpha) 10/20mcg/kg/min |
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How supplied |
Prefilled syringes and ampules of either 400 or 800mg. Premix bags with either 400 or 800 mg in 250-500ml. Concentrations of mixtures vary but most commonly are 1600 mcg/ml |
