Dopamine

Front 1

DOPAMINE
Class/ MOA

Back 1

Class
Sympathomimetic, inotropic agent.
Mechanism of Action
Immediate metabolic precursor to Norepinephrine. Increases systemic vascular
resistance, dilate renal and splanchnic vasculature. Increases myocardial contractility
and stroke volume.

Front 2

DOPAMINE
I/CI

Back 2

Indications
Cardiogenic, septic or spinal shock, hypotension with low cardiac output states.
Distributive shock.
Contraindications
Hypovolemic shock, pheochromocytoma, tachydysrhythmias, VF.

Front 3

DOPAMINE
AR/DI

Back 3

Adverse Reactions
Cardiac dysrhythmias, hypertension, increased myocardial oxygen demand,
extravagation may cause tissue necrosis.
Drug Interactions
Incompatible in alkaline solutions.
MAOIs will enhance effects of dopamine.
Beta blockers may antagonize effects of dopamine.
When administered with Phenytoin: may cause hypotension, bradycardia and seizures

Front 4

DOPAMINE
How supplied

Back 4

How Supplied
200 mg / 5 ml - 400 mg / 5 ml prefilled syringes, ampules for IV infusion.
400 mg in 250 ml D5W premixed solutions.

Front 5

DOPAMINE
Dosages

Back 5

Dosage and Administration
Adult: 2- 20 mcg / kg / min. (Rate determined by physician).
Pediatric: 2 - 20 mcg / kg / min. (Rate determined by physician).

Front 6

DOPAMINE
DOA/ Specials

Back 6

Duration of Action
Onset: 1-4 minutes.
Peak Effect: 5-10 minutes.
Duration: Effects cease almost immediately after infusion shut off.
Special Considerations
Pregnancy safety not established.
Effects are dose-dependent
Dopaminergic response: 2-4 mcg / kg / min.: dilates vessels in kidneys; inc. urine output.
Beta-adrenergic response: 4-10 mcg / kg / min.: Increased chronotropy and inotropy
Adrenergic response: 10-20 mcg / kg / min.: Primarily alpha stimulant /
vasoconstriction.
Greater than 20 mcg / kg / min.: reversal of renal effects / override alpha effects.
Always monitor drip rate.
Avoid extravagation injury.