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25 Cards in this Set
- Front
- Back
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Poxviridae
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Family of Class I DNA viruses. Enveloped. Largest viruses after mimivirus. Cause dermatic pustules (pox).
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Poxviridae Members
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Smallpox, cowpox, molluscum contagiosum. NOT syphilis or chickenpox.
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Chordopoxvirinae
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Subfamily of organisms with back bones. Genus Molluscipoxvirus and Genus Orthopoxvirus cause disease in humans.
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Entomopoxvirinae
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3 genera of insect viruses.
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Molluscum Contagiosum
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Prevalent, 4 serotypes. Transmission thru contact or fomites. Symptomatic papules. MCV-1 face, trunk, limbs in children via team sports. MCV-2 midsection in adults via sex.
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MCV & Wart Treatment
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Often self-resolving. At home: wart remover, Retin-A, duct tape (impractical, 6 weeks), cotton ball soaked in apple cider vinegar (24 hrs). Clinical: liquid nitrogen, laser, Cantharadin (blistering agent).
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Smallpox Transmission
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Only in humans. Physical or close contact necessary: infected saliva expelled & respiratory particles inhaled by noninfected.
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Smallpox Symptoms
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Fever and malaise. Rash from head down: Day 3 macule, Day 4-5 papule, Day 7 vesicle, Day 9 pustule, Day 13 scab.
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Smallpox Treatment
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Isolation. Vaccine 1-4 days after exposure helps. "Off label" Cidofovir - not intended to treat smallpox. Vaccinia antibodies (passive immunization).
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Smallpox Vaccine
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Dryvax (live vaccinia virus). 95% effective. Bifurcated needle punctures skin and reaction should develop.
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Verruca Warts
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Class I. Nonenveloped icosahedral. Caused by papillomaviridae or polyomaviridae.
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Wart Transmission
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Autoinnoculation, direct, or indirect.
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Wart Symptoms
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Common (high-contact areas), filiform (eyelid, armpit, neck), genital, flat (face, hand, wrist), plantar (foot).
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Cancerous Warts
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HPV-16 and HPV-18 (possibly -3, -6, and -11) cause cervical cancer. May cause penile cancer.
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Wart Prevention & Control
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Gardasil vaccine: synthetic structured vaccine (capsomer units) given in 3 doses.
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Hepatitis
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Inflammation of the liver: destroys hepatocytes, infiltrates immune system, causes swelling resulting in dysfunction. Jaundice - yellowing of eyes and skin.
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Hepatitis A
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Picornaviridae, Class IV. Fecal-oral, direct or indirect transmission. Ig or fluid treatment.
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Hep A Vaccines
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Havrix-R and Vaqtar inactivated, use aluminum hydroxide as an adjuvant.
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Hepatitis B
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Hepadnaviridae, Class VII. Blood, sex, congenital transmission. Ig, IFN, nucleoside analogue treatments.
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Hep B Vaccines
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Engerix-B, Recombivax, and H-B Vax II recombinant HBsAg surface antigen in yeast cells. Heptavax-B plasma-derived foreign use.
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Hepatitis C
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Flaviviridae, Class IV. Blood or congenital transmission. IFN & ribavirin treatments.
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Hepatitis D
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Delta agent, requires HBsAg. Satellite nucleic acid, Class V. Transmitted w/ Hep B. Same treatment as Hep B.
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Hepatitis E
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Caliciviridae, Class IV. Fecal-oral, direct or indirect transmission. No treatment.
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Hepatitis G
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Flaviviridae, Class IV. Blood transmission. No treatment or prevention.
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IFN Treatment
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Produced by leukocytes and fibroblasts. Antiviral and anticancer. Pegylated and recombinant in hepatitides.
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