Dna Synthesis

Front 1

- Replication Fork

Back 1

Two are formed at one origin of replication

- Unwound by Helicase

-Consists of many proteins (Helicase, DNA Primase, DNA polym, Single Stranded Binding Protein)

Front 2

- DNA Polymerase

Back 2

Synthesizes DNA 5'--> 3'

Removes RNA primer on lagging strands

A lot more stuff but I don't really get it yet. Somehow attached to lockign ring at times, single strands at another.

Front 3

- Helicase

Back 3

`unwinds DNA helix
- There's two of 'em

Front 4

- telomere

Back 4

cap of repeating DNA on a chromsome to lengthen the lagging strands 5' end so that know DNA is left uncopied.

- Synthesized from repeating RNA strands of telomerases
- shorter and shorter every mitotic division ( Telomerases inactive during mitosis)
- regenerated during meiosis (thanks to telomerase activity)

Front 5

- Telomerase

Back 5

Activates during meiosis to regenerate telomere

Front 6

- Primosome

Back 6

complex that sunthesizes RNA Primer ?!!?!?

Front 7

- Locking ring

Back 7

keeps DNA polymerase from letting go of strand

- on leading strand, It remains bound to DNA polym for most of the length

- On lagging strand, it lets go

Front 8

- Process of lagging strand synthesis (Steps)

Back 8

1. DNA Polymerases associate together and begin replicatoin
2. Lagging polym. hits okazaki fragment 5' end and stalls
3. Locking ring falls of DNA polym, but DNA polym remains bound to leading strand, ready for next fragment.
4. Lagging strand DNA dissociates from the polymerase and binds to the RNA primer synthesized by DNA primase
5. Locking ring reattaches to the polymerase which then displaces the single strand binding proteins as it synthesizes DNA 5' to 3'

Front 9

- Single Stranded Binding Protein

Back 9

Holds single strand DNA in place

- stabilizes it and keeps bases exposed so that transcription cna continue
- prevents hairpin structures from forming

Front 10

- DNA Primase

Back 10

Makes RNA primer