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25 Cards in this Set
- Front
- Back
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Papovaviridae include
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polyomaviadae and papillomvirdae
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get thicken of skin (karetin)Warts.. Get in by subcutaneous or mucas, 70% of cervical cancer
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papovaviirus (HPV0
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S-40 oncogenic virus (monkeys) containminated polio therory?
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polyoma virus
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2. More than 47 viruses known to cause disease in humans
i. Respiratory infections ii. Pink eye (conjunctivitis) iii. Pharyngoconjunctival fever in infants iv. Gastroenteritis v. Many infections subclinical in adults 3. Droplet or fecal oral transmission 4. Used as a vector for gene therapy |
Adenovirus family
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latent in neurons above waist (TRIGEMINAL GANGLIA) no vaccine, treat with acyclour
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HSV 1
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STD (gentials) below the waist It is in the lumbar and sacral (neurons)
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HSV 2
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a. can be acquired through infection of cuts –
people at risk |
herpetic whitlow
EITHER HSV-1 or HSV-2 Dentist, Nurse, people who suck there thumbs |
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3. mucoepithelial cells – latent in neurons – respiratory and close contact transmission
live vac. kids and old people |
Varicella Zoster – chicken pox/shingles –
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4. – monocytes, lymphocytes and epithelial cells, latent in monocytes and lymphocytes – close contact, transfusions, tissues, congenital
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Cytomegalovirus
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5. infectious mono - B cells and epithelial cells – latent in B cells – transmitted via saliva
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EBV
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Can diagnosis with hetrophilic antibody. Your serum to sheep RBCs clumping, Burkitt lymph
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EBV
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immunosuppressed patients, pregnant woman can infect fetus, looks like the cold with have a cough, CPE
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CMV
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– infects and becomes latent in lymphoid cells – Kaposi’s sarcoma – AIDS pts, CMI imp.
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Herpes virus 8
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1. Multiply in cytoplasm
2. Large complex viruses – some of the largest 3. This family includes variola (one variola virus causes smallpox) |
POX Virus
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1. – wart lesions – much harder to spread than smallpox – close contact, sex and fomites
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Molluscum contagiosum
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related to but milder than smallpox
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monkey pox
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Vaccinia virus
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cowpox
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1. Small SS naked DNA virus
2. Small viruses often need growing cells to replicate 3. Strain B19 causes Fifth disease |
Parvo virus
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1. SS + strand naked RNA icosahedral capsid (replicates in cytoplasm)
a. Plus strand RNA viruses look like mRNA b. WARNING: a naked genome can infect a cell 2. All stable in heat and detergent – all EXCEPT rhinovirus stable in acid 3. Brings in enzymes a. Proteases b. RNA dependent RNA polymerase 4. More than 230 members |
Picorna virus
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3 most imp. family members of Picornavirses
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Hepatoptovirus, Enterovirus and Rhinovirus
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1. Polioviruses, Coxsackie viruses, Echoviruses (rare)
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At least 71 serotypes of human Enteroviruses -
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2. very resistant to harsh environmental conditions including GI tract and sewage systems - often fecal oral transmission
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Capsids of Enteroviruses
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1. Spread by fecal contamination in water
2. Replicates in pharynx and GI tract before entering bloodstream 3. Goes from bloodstream to CNS 4. Cytolytic for motor neurons hence paralysis a. Loss of neurons, paralysis with age called post polio syndrome b. No virus detected in post polio syndrome, so not a result of latency 5. Paralytic __________ is still prevalent in Africa and remains endemic in Afghanistan, Pakistan, India, and Nigeria |
Poliovirus
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a. Herpangina – caused __________ A NOT related to herpesvirus
b. Hand, foot and mouth - Coxscakievirus A16 c. Conjunctivitis |
Coxsackie, Group A
Enterovirus family |
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a. Pleurodynia (Bornholm disease)
b. Myocardial and pericardial infections |
Group B, Coxsackievirus
Enteroviris family |
