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12 Cards in this Set
- Front
- Back
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Hydroxyurea
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inhibits ribonucleotide reductase --> decreasing availablity of deoxynucleotides for DNA synthesis (all of them)
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5-FU/F-dUMP
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orotate phosphoribosyl transferase makes F-dUMP, which is a competitive inhibitor of thymidylate synthesis
a folate analogue is often prescribed in conjunction |
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Methotrexate
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inhibits dihydrofolate reductase (less THF)
thus, decreased production of methyl-THF and N5- N10 methyleneTHF which are are req for purine and pyrimidine synthesis a folate analogue is often prescribed in conjunction |
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6-Mercaptopurine
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blocks de nove synthesis of purine nucleotides (affects both RNA and DNA synthesis)
used for ALL and non-Hodgkns lymphoma |
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Trimethoprim
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inhibits BACTERIAL dihydrofolate reductase = an antibiotic
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Allopurinol
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Gout treatment
xanthine oxidase inhibitor - comp inhib of xo leading to inc. excretion of xanthine and hypoxanthine - use up PRPP to reduce purine biosynthesis - its analogue ribotide can inhibit PRPP amidotransferase - pos force HGPT to make more IMP from hypoxanthine |
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Febuxostat
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xanthine oxidase inhibitor
not metabolized by kidneys |
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Probenecid
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(Benemid)
inhibits uric acid reabsorption, thus lowering blood conc of uric acid, inc excretion |
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Sulfinpyrazone
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(Anturane)
inhibits uric acid reabsorption, thus lowering blood conc of uric acid, inc excretion |
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Disulfiram
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Aldehyde Dehydrogenase Inhibitor
- alcoholism aversive therapy - buildup of aldehyde causing noxious effects |
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Fomepizole
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ADH inhibitor (alcohol dehydrogenase inhibitor)
- treatment for methanol poisoning (block production of formaldehyde and formic acid) |
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Lactulose
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used to treat hyperammonemia
micoorganisms in the intestines break lactulose down, acidifying the lumen. This converts the NH3 produced by bacteria to be protonated to NH4+ which is not readily absorbed across the intestinal epithelium (excreted) |
