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17 Cards in this Set
- Front
- Back
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in terms of inflammation, how does early RA compare to late RA?
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early RA has more inflammation
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when does RA progress the most?
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in the first year
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how does methotrexate work? classification? uses? side effects?
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inhibits purine synthesis via dihydrofolate reductase (must supply folic acid as well)good long term efficacy and tolerable, it is a common DMARD. used for mod. to severe RA. S.E. are stomatitis, marrow suppresion, hepatic fibrosis, pneumonitis
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describe leflunomide, uses, side effects...
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inhibits pyrimidine synth. decreases radiographic progression and improves physical function. used for moderate to severe RA. SE: diarrhea, alopecia, liver enzymes and marrow suppression.
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describe sulfasalazine, uses, side effects...
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suppresses various leukocyte/lymphocyte finctions. used for mild to moderate RA. SE are nausea/diarhea, hepatitis, marrow suppresion
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describe hydroxycholoroquine, uses, side effects...
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interferes with antigen presentation. used in mild, early RA. SE are nausea, retinal toxicity, and blurred vision
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what are the classic dmards?
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methotrexate, sulfasalazine, leflunomide, and hydroxycholoroquine
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what is the main difference between common dmards and biologic dmards?
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biologic dmards are specefic cell suppressors unlike traditional ones that are non specefic
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what are the three approaches to cytokine blocking used in some dmards?
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monoclonal antibodies or soluble receptors bind the cytokine before it binds the cell, receptor antagonists or antibodies can bind to cytokine receptors to block cytokines, and anti inflammatory cytokines can be administered to prevent the production of inflammatory cytokines
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Anti TNF agents are biologic DMARDs that prevent cytokine binding to the cell. what are there names and what type of compound are they?
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monoclonal antibodies: inflixamab and adalimumab
soluble receptor: entanercept |
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what biologic dmard is an anti L1 cytokine agent that is a receptor antagonist?
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anakinra
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which TNF antagonist uses mouse chains in its antibody?
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infliximab
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what diseases can biologic dmards that are anti TNF's be used for?
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RA, psoriatic arthritis, ankylosing spondylitis, crohn's disease (inflixamab only), and psoriasis
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how does abatacept work?
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alters the interaction between T cells and APC by preventing interaction of CD28 and CD80/86 AKA the costimulatory signal
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how does rituximab work?
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it is a chimeric monoclonal antibody against the CD20 antigen of B lymphocytes
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what major infection was associated with anakinra?
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pneumonia
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what major infection was associated with infliximab and etanercept?
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TB
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