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17 Cards in this Set

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in terms of inflammation, how does early RA compare to late RA?
early RA has more inflammation
when does RA progress the most?
in the first year
how does methotrexate work? classification? uses? side effects?
inhibits purine synthesis via dihydrofolate reductase (must supply folic acid as well)good long term efficacy and tolerable, it is a common DMARD. used for mod. to severe RA. S.E. are stomatitis, marrow suppresion, hepatic fibrosis, pneumonitis
describe leflunomide, uses, side effects...
inhibits pyrimidine synth. decreases radiographic progression and improves physical function. used for moderate to severe RA. SE: diarrhea, alopecia, liver enzymes and marrow suppression.
describe sulfasalazine, uses, side effects...
suppresses various leukocyte/lymphocyte finctions. used for mild to moderate RA. SE are nausea/diarhea, hepatitis, marrow suppresion
describe hydroxycholoroquine, uses, side effects...
interferes with antigen presentation. used in mild, early RA. SE are nausea, retinal toxicity, and blurred vision
what are the classic dmards?
methotrexate, sulfasalazine, leflunomide, and hydroxycholoroquine
what is the main difference between common dmards and biologic dmards?
biologic dmards are specefic cell suppressors unlike traditional ones that are non specefic
what are the three approaches to cytokine blocking used in some dmards?
monoclonal antibodies or soluble receptors bind the cytokine before it binds the cell, receptor antagonists or antibodies can bind to cytokine receptors to block cytokines, and anti inflammatory cytokines can be administered to prevent the production of inflammatory cytokines
Anti TNF agents are biologic DMARDs that prevent cytokine binding to the cell. what are there names and what type of compound are they?
monoclonal antibodies: inflixamab and adalimumab
soluble receptor: entanercept
what biologic dmard is an anti L1 cytokine agent that is a receptor antagonist?
anakinra
which TNF antagonist uses mouse chains in its antibody?
infliximab
what diseases can biologic dmards that are anti TNF's be used for?
RA, psoriatic arthritis, ankylosing spondylitis, crohn's disease (inflixamab only), and psoriasis
how does abatacept work?
alters the interaction between T cells and APC by preventing interaction of CD28 and CD80/86 AKA the costimulatory signal
how does rituximab work?
it is a chimeric monoclonal antibody against the CD20 antigen of B lymphocytes
what major infection was associated with anakinra?
pneumonia
what major infection was associated with infliximab and etanercept?
TB