Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
36 Cards in this Set
- Front
- Back
|
What are the two most important goals of rheumatoid arthritis management at the cellular level?
|
Knock out T and B lymphocytes,Inhibit proinflamatory cytokines TNF and Interleukin 1, 6
|
|
|
What are the four categories of rheumatoid arthritis drugs?
|
NSAIDs,Glucocorticoids,DMARDs,Biological agents
|
|
|
What vitamin supplement should be given with methotrexate and what dietary counsel should be given?
|
folate supplement,no alcohol
|
|
|
What is the mechanism of sulfasalazine?
|
inhibits prostaglandin production
|
|
|
What drug inhibits mitochondrial dihydroorotate dehydrogenase?
|
Leflunomide
|
|
|
What rheumatoid arthritis drug is 100% contraindicated in patients with hepatic dysfunction?
|
leflunomide
|
|
|
What is the action of the biological response factors used in RA management?
|
inhibit TNF,inhibit interleukin 1
|
|
|
What are the TNF antagonists used in RA?
|
Etanercept,Infliximab,Adalimumab
|
|
|
What is the biological agent used in RA that is an IL-1 receptor antagonist?
|
anakinra (Kineret)
|
|
|
What biological agent used in RA is a costimulation blocker?
|
Abatacept (Orencia)
|
|
|
What biological agent used in RA is an anti-CD20 monoclonal antibody?
|
Rituximab (Rituxan)
|
|
|
What is the mechanism of etercept?
|
prevents binding of TNF to receptor
|
|
|
What is the mechanism of action of infliximab?
|
binds to TNF alpha and inactivates it
|
|
|
What is the mechanism of action of adalimumab?
|
Prevents binding of TNF to receptor,Lysis of TNF expressing cells
|
|
|
How is Anakinra administered?
|
Daily SC administration
|
|
|
Biological Response Modifiers used in RA are contraindicated in what patients?
|
Those with acute infection,immunocompromised,tuberculosis
|
|
|
What are the proinflammatory cytokines involved in Rheumatoid Arthritis?
|
TNF alpha,IL-1,IL-6,IL-17
|
|
|
What are the DMARDs?
|
Methotrexate,Hydroxychloroquine,Sulfasalazine,Leflunomaide
|
|
|
What DMARD inhibits dihydrofolate reductase?
|
Methotrexate
|
|
|
How often is methotrexate administered?
|
once weekly
|
|
|
What are the serious adverse reactions to methotrexate?
|
hepatotoxicity and pulmonary fibrosis
|
|
|
What antimalarial drug is used for treatment of chronic rheumatoid arthritis?
|
hydroxylchorquinone
|
|
|
What DMARD inhibits lymphocyte function, stabilizes lysosomal membranes, reduces chemotaxis and phagocytosis and reduces IL I production?
|
hydroxylchorquinone
|
|
|
What DMARD is converted in the intestine to sulfapyradine and mesalamine?,What are the effects of those metabolites?
|
sulfasalazine,sulfapyradine-antimicrobial ,mesalamine-antiinflammatory
|
|
|
Why is the use of sulfasalazine limited?
|
serious GI side effects
|
|
|
What drug inhibits dihydroorotate dehydrogenase?
|
leflonamide
|
|
|
What DMARD inhibits T lymphocyte response to inflammatory stimuli?
|
leflonamide
|
|
|
What are the contraindications for Leflonamide use?
|
hepatic dysfunction
|
|
|
What are the adverse reactions of etenercept?
|
injection site reaction,headache,dizziness
|
|
|
Which biological agent used in RA treatment prevents IL-1 receptor binding?
|
Anakinra
|
|
|
Anakinra is contraindicated in combination with what other drugs?
|
TNF antagonists
|
|
|
What biological agent used in RA treatment blocks T cell signaling and T-cell activation?
|
Abatacept (Orencia)
|
|
|
How often is abatacept administered?
|
every 4 weeks
|
|
|
Antihypertensive therapy should be withheld for 12 hours prior to the administration of what biological agent used in RA?
|
Rituximab (Rituxan)
|
|
|
What biological agent used in RA causes rapid and sustaine depletion of B-lymphocytes?
|
Rituximab (Rituxan)
|
|
|
What are the adverse effects of rituximab?
|
angioedema,fatigue,nausea,vomiting,headache,hypotension,bronchospasm,rash,urticaria
|
