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33 Cards in this Set
- Front
- Back
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How does Na move as it moves along a nephron?
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PCT: 2/3 is reabsorbed
Desc Loop: impermeable Thin Asc Limb: passive reabs Thick Asc Limb: Transported DCT: reabsorbed (transported) Collecting Duct: ENaC moves it |
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Na Movement in Proximal Tubule is via?
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Na Co-Transporter (w/ glucose, phosphate, or AA's)
Na/H Exchanger NaCl Co-transporter |
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How is Na moved in Thick Asc Limb?
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Na/K/2Cl Co-Transporter
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what part of the nephron is impermeable to water?
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Asc Limb
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How is Na moved in DCT?
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NaCl Co-Transporter (different one than in Prox Tubule)
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what other ion is affected by NaCl Co-Transporter in DCT?
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Calcium
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Who moves Na in the cortical and maybe medullary Collecting Ducts?
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ENaC
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What is responsible for activating/increasing ENaC?
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Aldosterone does in the cortical CD's, but not medullary
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what is another ionic role of the collecting duct?
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H+ secretion to maintain pH
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Regulators of Na Excretion?
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GFR
Aldosterone Atrial Natriuretic Peptide Pressure Natriuresis Natritropes |
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Examples of natritropes?
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Sympathetic nerves
Ang II NO Endothelin |
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Regulation of H2O excretion?
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passive reabsorption
ADH aka vasopressin |
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Regulation of K+ Excretion?
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Passive Reabsorption and Secretion
Aldosterone increases K transporters in response to inc in plasma [K] Tubular Flow Rate (inc TFR-->Inc K excretion |
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General Classes of Diuretics?
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Osmotic
Mercurial Carbonic Anhydrase Inhibitors Thiazides Loop K-Sparing |
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Kickers w/ Osmotic Diuretics?
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Non-Reabsorbable Solute
Expands ECF Volume = bad for CHF |
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Main example of osmotic diuretics?
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Mannitol
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Kickers with Carbonic Anhydrase Inhibitors?
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More useful in acid/base issues
Weak diuretic b/c it works almost exclusively in proximal tubule Good for acute mountain sickness |
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Mechanism of Loop Diuretics/
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Blocks Na/K/Cl transporter of thick ascending limb
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Why are loops good?
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they get rid of lots real fast
cheap Orally bioavailable |
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Indications for Loops?
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HTN
Pulm Edema Acute Renal Failure CHF!!! |
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SE's of Loop Diuretics?
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Hyperglycemia
Ototoxicity Hypokalemic Alkalosis |
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Mech of Thiazide Diuretics?
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Inhibit NaCl Co-Transporter in Distal Tubule
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Other effects of Thiazide Diuretics?
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Enhance Ca reabsorption
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Indications of Thiazide Diuretics?
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HTN
CHF Kidney Stones very safe w/ few side effects |
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Containdications of Thiazide Diuretics?
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Antidiuretic in Diabetes Insipidus
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Effects of Aldosterone Antagonists on ions?
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Inc Na Excretion
Dec K excretion |
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Examples of Aldo Antagonists?
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Spironolactone
Eplerenone |
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Indications for Aldo Antagonists?
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Hyperaldosteronism
Adjunct w/ other diuretics HTN |
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SE's of Aldo Antagonists?
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Hyperkalemia
Acidosis Gynecomastia |
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Mech of Na Entry Blockers?
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Block ENaC
K-Sparing |
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Examples of Na Entry Blockers?
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Amiloride
Triampterene |
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Indications of Na Entry Blockers?
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Adjunct with other diuretics
Hypokalemia HTN Edema |
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SE's of Na Entry Blockers
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Hyperkalemia
Acidosis |
