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8 Cards in this Set
- Front
- Back
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ACETAZOLAMIDE
(DORZOLAMIDE) |
Carbonic anhydrase inhibitors (blocks bicarbonate reabsorption)
Act in PCT Use: Glaucoma, urinary alkalinisation, mountain sickness, metabolic alkalosis AE: metabolic acidosis, renal stones, K+ loss, hepatic encephalopathy |
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MANNITOL
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Osmotic diuretic
Use: maintain tubular flow, reduces intracranial & intraocular pressure AE: immediate ECF volume expansion, hypernatremia |
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FUROSEMIDE
(BUMETANIDE, TORSEMIDE, ETHACRYNIC ACID) |
Loop diuretic - K wasting diuretic
Acts in the TAL to inhibit the Na/K/Cl transporter Use: emergency edematous conditions (acute pulm edema, acute CHF), acute hyperCa++ or K+, tx of acute oliguria, anion overdose, refractory HTN or CHF AE: hypokalemia, metabolic alkalosis, ototoxicity, hyperuricemia, hypermagnesemia, allergic rxn |
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HYDROCHLOROTHIAZIDE
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Inhibit NaCl symporter in DCT
Uses: HTN, CHF, kidney stones due to idiopathic hypercalciuria (enhances Ca++ reab), nephrogenic diabetes insipidus AE: hypokalemia, metabolic alkalosis, hyperuricemia, hypernatremia, impiared carb tolerance, hyperlipidemia |
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METOLAZONE
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Related to thiazides but also effective at low GFR
Uses: HTN, edema, combination treatment w thiazides |
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TRIAMTERENE
AMILORIDE |
K+ sparing diuretics
Blocks aldosterone and Na channel in collecting tubule Use: combo w thiazide AE: hyperkalemia, aggravated by B blockers, ACE inhibitors, metabolic acidosis (Triamterene - acute renal failure, kidney stones) |
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SPIRONOLACTONE
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K+ sparing, aldosterone antag in collecting tubule
Use: HTN, CHF AE: hyperkalemia, aggravated by B blockers & ACE inhibitors, metabolic acidosis, gynecomastia |
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NESIRITIDE
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B type natriuretic peptide
Antag for renin, angiotensin II, aldosterone, ADH Uses: acute severe heart failure |
