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20 Cards in this Set
- Front
- Back
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What is the MoA and LoA for acetazolamide? |
Carbonic anhydrase inhibitor
acts on PCT |
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What are side-effects for acetazolamide? (5) |
- Metabolic acidosis - Sedation - Paresthesia - Bone marrow depression - Hypersensitivities |
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For what other condition is acetazolamide used besides diuresis? |
eye-drops for glaucoma |
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What is the MoA and LoA of Loop diuretics? |
Inhibit Na/2Cl/K symporter
Ascending Loop of Henle |
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What are the side-effects of Loop diuretics? (6) |
- Hypokalemia - Hyponatremia - Hypocalcemia - Hyperuricemia - Ventricular arrhythmia - Ototoxicity |
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What drug diminishes the effects of Loop diuretics? |
NSAIDs |
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What is the MoA and LoA of thiazide diuretics? |
Inhibition of Na/K symporter
DCT |
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Name two thiazides. |
1) Hydrochlorothiazide 2) Chlorthalidone |
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What are the side-effects of thiazides. (6) |
- Ventricular arrhythmias - Muscle weakness - Impotence - Hyperuricemia - Hyperglycemia - Hypersensitivity |
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What drugs blunt the effects of thiazides? |
NSAIDs |
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Name the MoA or LoA of Potassium-sparing diuretics. |
Block sodium channels or aldosterone receptors
CT |
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Name two K-sparing drugs that inhibit Na-channels in the CT. |
- Amiloride - Triamterene |
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Name two K-sparing drugs that block the aldosterone receptors in the CT. |
- Spironolactone - Eplerenone |
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What are the side-effects of the aldosterone receptor inhibitors? (4) |
- Gynecomastia - Reduced libido - Impotence - Menstrual irregularities |
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What is the MoA of Aliskerin? |
Renin-inhibitor |
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Which Angiotensin receptor does Lorsartan block? |
AT1R |
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What is a unique side-effect of ACE-inhibitors? |
- persistent cough |
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What are side-effects of ACE-inhibitors and AT1R blockers? (3) |
- Angioedema - Loss of taste - Hypotension |
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With what patients should Aliskerin not be used with ACE-inhibitors or AT1R blockers? |
Diabetics |
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Which diuretics should not be prescribed to pregnant women or women who plan to be pregnant? |
- ACE-inhibitors - AT1R blockers |
