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35 Cards in this Set
- Front
- Back
Which diuretics are used for hypertension
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Thiazides
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Indapamide - what class of diuretics
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Thiazide
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This type of diuretic is drug of choice for CHF, also increase urinary Ca excretion, to treat hypercalcemia
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Loop diuretics
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Aldosterone antagonist which is contraindicated in patients with impaired renal function or type II diabetes with proteinuria - causes hyperkalemia
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Eplerenone
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This aldosterone antagonist causes gynecomastia in 10% of male patients
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Spironolactone
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Typically considered to be K sparing but more potent agents with slow onset of action
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Aldosterone antagonists
- Eplerenone - Spironolactone |
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Name potassiium sparing diuretics
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Amiloride
Triamterene |
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3 signs of hypokalemia
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Muscle rigidity
Muscle fatigue Muscle cramps |
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These drugs remain basis of treatment in patients with CHF
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Diuretics + ACE inhibitors
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At what dose should you generally start diuretics
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Start at low dose and increase dose according to clinical response
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Which diuretics are used to treat hypercalcemia
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Loop diuretics
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Which diuretics have rapid onset of action
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Loop diuretics
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What lab tests should you monitor in patients on loop diuretics
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Serum electrolytes and renal function
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Relatively common adverse effect of loop diuretics in treatment with high dose IV diuretics
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Acute gout
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Adverse effect of loop diuretics that can precipitate arrhythmia
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Hypokalemia
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In a patient who is takin thiazide diuretics you want GFR to be
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30
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Which adverse effects are commonly associated with higher doses of thiazide diuretics
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Hyponatremia and hypokalemia
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A thiazide like diuretic that can be synergistically used with loop diuretic - double nephron blockade
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Metolazone
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Metolazone is contraindicated in patients with _
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Liver failure
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Competitive aldosterone inhibitor
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Spironolactone
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Pottasium sparing diuretics should be used with caution in patients receiving _ owing to potential risk of _
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ACE inhibitors
Hyperkalemia |
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Diuretics in combination with what drug can cause severe hypokalemia
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Digitalis
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Which diuretics should be avoided in patients with gout
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THiazide
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This drug has less adverse effects on lipid panel than other thiazides
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Indapamide
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Thiazides are contraindicated in _
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Renal failure
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Which is the only loop diuretic that be taken in patient with sulfa allergy
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Ethacrynic acid
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What is the toxicity caused by ethacrynic acid
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ototoxic
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What is the main adverse effect of K sparing diuretics
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Hyperkalemia especially in patient with renal impairment
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Which thiazide has length of duration of 18-24 hours
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Indapamide
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Which thiazide has duration of more than 24 hours
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Chlorothiazide
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WHich thiazide has duration of 12-18 hours
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Hydrochlorothiazide
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Which loop diuretic is long acting 18-24 hours
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Torsemide
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Short acting loop diuretic that can be used in patients with skin rash or photosensitivity to thiazide - this is the only diuretic that doesnt contain sulfur component. Which toxicity has been noticed when its taken in large dose
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Ethacrynic acid
Ototoxicity |
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Name drugs that cause increased anti hypertensive effects if used with diuretics
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ACE inhibitors
Antipsychotics Antiadrenergic agents Beta blockers Ethanol |
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Name drugs that cause decreased anti-hypertensive effects if used with diuretics
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ASA/NSAID
Anticonvulsant Bile acid resins Sympathomimetics (albuterol, dobutamine) |