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35 Cards in this Set

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Which diuretics are used for hypertension
Thiazides
Indapamide - what class of diuretics
Thiazide
This type of diuretic is drug of choice for CHF, also increase urinary Ca excretion, to treat hypercalcemia
Loop diuretics
Aldosterone antagonist which is contraindicated in patients with impaired renal function or type II diabetes with proteinuria - causes hyperkalemia
Eplerenone
This aldosterone antagonist causes gynecomastia in 10% of male patients
Spironolactone
Typically considered to be K sparing but more potent agents with slow onset of action
Aldosterone antagonists

- Eplerenone
- Spironolactone
Name potassiium sparing diuretics
Amiloride

Triamterene
3 signs of hypokalemia
Muscle rigidity

Muscle fatigue

Muscle cramps
These drugs remain basis of treatment in patients with CHF
Diuretics + ACE inhibitors
At what dose should you generally start diuretics
Start at low dose and increase dose according to clinical response
Which diuretics are used to treat hypercalcemia
Loop diuretics
Which diuretics have rapid onset of action
Loop diuretics
What lab tests should you monitor in patients on loop diuretics
Serum electrolytes and renal function
Relatively common adverse effect of loop diuretics in treatment with high dose IV diuretics
Acute gout
Adverse effect of loop diuretics that can precipitate arrhythmia
Hypokalemia
In a patient who is takin thiazide diuretics you want GFR to be
30
Which adverse effects are commonly associated with higher doses of thiazide diuretics
Hyponatremia and hypokalemia
A thiazide like diuretic that can be synergistically used with loop diuretic - double nephron blockade
Metolazone
Metolazone is contraindicated in patients with _
Liver failure
Competitive aldosterone inhibitor
Spironolactone
Pottasium sparing diuretics should be used with caution in patients receiving _ owing to potential risk of _
ACE inhibitors

Hyperkalemia
Diuretics in combination with what drug can cause severe hypokalemia
Digitalis
Which diuretics should be avoided in patients with gout
THiazide
This drug has less adverse effects on lipid panel than other thiazides
Indapamide
Thiazides are contraindicated in _
Renal failure
Which is the only loop diuretic that be taken in patient with sulfa allergy
Ethacrynic acid
What is the toxicity caused by ethacrynic acid
ototoxic
What is the main adverse effect of K sparing diuretics
Hyperkalemia especially in patient with renal impairment
Which thiazide has length of duration of 18-24 hours
Indapamide
Which thiazide has duration of more than 24 hours
Chlorothiazide
WHich thiazide has duration of 12-18 hours
Hydrochlorothiazide
Which loop diuretic is long acting 18-24 hours
Torsemide
Short acting loop diuretic that can be used in patients with skin rash or photosensitivity to thiazide - this is the only diuretic that doesnt contain sulfur component. Which toxicity has been noticed when its taken in large dose
Ethacrynic acid

Ototoxicity
Name drugs that cause increased anti hypertensive effects if used with diuretics
ACE inhibitors
Antipsychotics
Antiadrenergic agents
Beta blockers
Ethanol
Name drugs that cause decreased anti-hypertensive effects if used with diuretics
ASA/NSAID
Anticonvulsant
Bile acid resins
Sympathomimetics (albuterol, dobutamine)