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25 Cards in this Set
- Front
- Back
- 3rd side (hint)
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These diuretics interfere with the Na-Cl channel
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Thiazides
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This class class inhibits CA and increase calcium resorption.
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Thiazides. The sulfonamide dervatives are thought to also be CA inhibitors.
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These diuretics increase excretion of Calcium.
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Loop diuretics. By what mechanism?
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They remove Na and Cl. Na is needed for Calcium later on.
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These diuretics are indicated in renal calcium stones
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Thiazides. Which are contraindicated?
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Loop diuretics because they increase renal Ca excretion.
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These diuretics work at the distal convoluted tubule.
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Thiazides. what are some essoteric thiazide like drugs?
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metalazone and indapamide
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This drug is good for meinier's disease
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HZT. Reduces endolymph. What do you give for menetrier's disease?
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TGF-alfa blocker cetuxumab. This is a lymphocytic cancer that causes big ruggae.
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What metabolic imbalances can be expected with HTZ use?
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hypokalemia,hypochloridic alkalosis.
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Inhibit Na/Cl/2K pump
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Loop diurretics like bumetanide and furosamide.
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What is the fastest diuretic?
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All of them are 1 to 2 hours. But loops work in minutes.
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Which drug can cause alkalosis?
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Loops. They inhibit K reabsorption and make H/K system hard to work.
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This diuretic can cause ototoxicity
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Loops. this one causes aucustic neuroma?
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none. Ototoxicity is something different.
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These inhibit aldosterone
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K sparring.
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These drugs are never used on there own
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K sparing like triamterene or spironolactone. they work best in combonation with HTZ
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What kind of drug is triampetrene.
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it is NOT an aldosterone receptor drug. it binds ENAC like Amiloride.
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ENAC drugs are in what class?
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K sparring. What are common side effects?
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Hyperkalemia with arrythmias.
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These drugs can treat hyperaldosteronism
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K sparring. both ENAC and aldoblockers. they are working on the same axis.
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Dichlorphenamide is in what class?
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CA inhibitors
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What effects do CA inhibitors have on HCO3?
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They reduce resorption of HCO3 along with Na and inhibit excretion of H
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What effects do CA inhibitors have on urine pH
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they raise it. often within 30 min.
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What effects do CA inhibitors have on blood pH
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they lower it.
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Which are good for third spacing?
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mannitol (osmotic), glycerin, urea.
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Which diuretics are good for glaucoma?
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CA inhibitors
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Which are used in cerebral edema?
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Urea and Mannitol. What happens if you give saline too quickly?
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persons nerves swell. maybe if you give a diuretic too quickly as well.
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Which drugs work on vassopressin?
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Desmopressin.
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These can be used to increase excretion of urate and cystein.
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CA inhibitors. they raise pH to do this.recall crystalls melt at high pH.
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