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15 Cards in this Set
- Front
- Back
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Mannitol
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Osmotic diuretic: proximal tubule, thin descending loop, collecting duct
↓Intracranial Pressure, Shock, Drug Overdose Tox: pulmonary edema Contra: CHF |
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Acetazolamide
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Carbonic anhydrase inhibitor: PCT brush border
Glaucoma, Urinary Alkalinization, Metabolic Alkalosis, Altitude Sickness Tox: hyperchloremic metabolic acidosis (ACIDazolamide causes ACIDosis), sulfa allergy, NH3 toxicity |
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Furosemide
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Sulfonamide Loop Diuretic: inhibits NKCC co transporter in thick ascending loop; ↓Ca paracellular absorption
Edema, Hypertension, Hypercalcemia Tox: OTOTOXICITY, hypokalemia, hypocalcemia, alkalemia, sulfa allergy, interstitial nephritis, GOUT |
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Torsemide
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Sulfonamide Loop Diuretic: inhibits NKCC co transporter in thick ascending loop; ↓Ca paracellular absorption
Edema, Hypertension, Hypercalcemia Tox: OTOTOXICITY, hypokalemia, hypocalcemia, alkalemia, sulfa allergy, interstitial nephritis, GOUT |
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Bumetanide
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Sulfonamide Loop Diuretic: inhibits NKCC co transporter in thick ascending loop; ↓Ca paracellular absorption
Edema, Hypertension, Hypercalcemia Tox: OTOTOXICITY, hypokalemia, hypocalcemia, alkalemia, sulfa allergy, interstitial nephritis, GOUT |
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Ethacrynic Acid
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Non-Sulfa Loop Diuretic: inhibits NKCC co transporter in thick ascending loop; ↓Ca paracellular absorption
Diuresis in pts with sulfa allergies Tox: OTOTOXICITY, hypokalemia, hypocalcemia, alkalemia, interstitial nephritis, GOUT |
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Hydrochlorothiazide
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Thiazide diuretic: inhibits NaCl cotransporter in DCT; ↑Ca absorption
Hypertension, CHF Tox: Hypokalemic Metabolic Alkalosis, Hyponatremia HyperGLUC (glycemia, lipidemia, uricemia, calcemia) Sulfa allergy |
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Indapamide
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Thiazide diuretic: inhibits NaCl cotransporter in DCT; ↑Ca absorption
Hypertension, CHF Tox: Hypokalemic Metabolic Alkalosis, Hyponatremia HyperGLUC (glycemia, lipidemia, uricemia, calcemia) Sulfa allergy |
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Metazolone
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Thiazide diuretic: inhibits NaCl cotransporter in DCT; ↑Ca absorption
Hypertension, CHF Tox: Hypokalemic Metabolic Alkalosis, Hyponatremia HyperGLUC (glycemia, lipidemia, uricemia, calcemia) Sulfa allergy |
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Sprinolactone
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K+ sparing diuretic: competitive aldosterone receptor antagonist in CT
Hyperaldosteronism (Conn's syndrome), K+ depletion, CHF Tox: Hyperkalemia, Gynecomastia, Antiandrogen effects |
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Triamterone
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K+ sparing diuretic: block Na channels in CT
Hyperaldosteronism, K+ depletion, CHF Tox: Hyperkalemia |
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Amiloride
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K+ sparing diuretic: block Na channels in CT
Hyperaldosteronism, K+ depletion, CHF |
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Eplerenone
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K+ sparing diuretic: competitive aldosterone receptor antagonist in CT
Reduces cardiovascular risk POST-MI Tox: Hyperkalemia, Gynecomastia, Antiandrogen effects |
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-Prils
Captopril Enalapril Lisinopril |
ACE Inhibitor
DIABETIC Renal Disease, Hypertension, CHF Tox: Cough (ACE degrades bradykinin), HYPERKALEMIA, Taste Changes, Pregnancy Problems, Angioedema, Proteinuria Contra: bilateral renal artery stenosis due to ↓GFR |
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-Sartans
Losartan |
Angiotensin II Receptor Antagonist
Does not produce cough like ACE inhibitors |
