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22 Cards in this Set
- Front
- Back
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what are the cytokines secreted by macrophages?
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IL-1
IL-6 IL-8 IL-12 TNF-a |
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PMN chemotactic factors
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IL-8
C5a leukotriene B4 |
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interleukins 1-5
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HOT T-Bone-stEAk
1-fever 2- stimulates T cells 3- stimulates BONE marrow 4- stimulates IgE production 5- stimulates IgA production |
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IL-1
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endogenous pyrogen that causes fever and acute inflammation, activates endothelium to express adhesion molevules and recruits leukocytes
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IL-6
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endogenous pyrogen that is secreted by Th cells and macrophages
causes fever and stimulates production of acute-phase proteins |
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IL-8
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clean up on aisle 8- recruits PMN
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IL-12
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causes differentiation into Th1 cells
activates NK cells also secreted by B cells |
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TNF-a
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mediates septic shock
causes leuckocyte recruitment, vascular leak, activates endothelium |
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secreted by ALL t-cells
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IL-3- supports the growth and differentiation of bone marrow stem cells
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secreted by Th1 cells
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IL-2, interferon-y
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IL-2
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stimulates growth of helper and cytotoxic T cells
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interferon-y
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activates macrophages and Th1 cells; suppresses Th2 cells
antiviral and antitumor properties |
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secreted by Th2 cells
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IL-4
IL-5 IL-10 |
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IL-4
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induces differentiation into Th2 cells
promotes growth of B cells enhances class sqitching to IgE and IgG |
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IL-5
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"snot-producing"
promotes differentaiton of B cells enhances class switching to IgA stimulates the growth and differentiation of eosinophils |
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IL-10
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inhibitory
modulates inflammatory response inhibits actions of activated T cells and Th1 acitaves Th2 also secreted by Tregs! |
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Th2 cytokines...
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augment B cell development!
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interferons are proteins that...
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place uninfected cells in an antiviral state
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interferons induce the production of a __________
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ribonuclease that inhibits viral protein synthesis by degrading
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activated by interferons to kill virus infected cells
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NK cells
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alpha and beta interferons inhibit
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viral protein synthesis
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gamma interferons increase..
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MHC I and II expression and antigen presentation in all cells
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