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57 Cards in this Set
- Front
- Back
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has TCR CD3 CD28
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Tcells
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what does CD 28 bind to
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B7
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has CD4, CD3 CD 40L
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helper T cells
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has CD3, CD8 and TCR
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cyotoxic T cells
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Ig, CD 19, CD 20 , CD21, CD40, MHC II, B7
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B cells
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what is the receptor for EBV
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CD21
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what does CD 40L bind to
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CD 40 on B cells
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MHC II, B7, CD 40, CD 14, CD 16, receptors for Fc and C3b
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macrophages
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receptors for MHC I, CD 16, CD56,
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NK cells
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what are the 5 differnent types of heavy chain
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alpha, mu, gamma, delta, epsilon,
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what is the Fab fragment of antibody
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antigen binding fragment- heavy and light chains, 1 antigenic specificity expressed per B cell
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Fc region
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carboxy terminal, constant, heavy chains only, complement binding, carbohydrate side chains, determine isotype (IgM, IgD,IGA) recognized by CD 16
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what are the 2 kinds of light chains?
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lambda and kappa
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what is VDJ recombination?
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how B cells and T cells compose the coding regions for each specific anigen receptor on B cells and T cells. RAG 1 and RAG2 recognized RSS regions that flanks VDJ regions and mutations in RAG will lead to arrest of B cell and T cell development
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2ndary delayed response to antigen, most abundant in blod, crosses placenta, opsonizes bacteria, neurtalizes bacterial toxins and viruses
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IgG
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does not fix complement. monomer in circulation and dimer when secreted. in secretions and breast milk, travels across epithlium ( transcytosis)
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IgA
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primary immediate response to antigen, monomer on B cell and pentamer whne activated, fixes complement
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IgM
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on surface of b cells
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IgD
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binds mast cells and basophils, cross linke when exposed to allergen causing Type I hypersensitivity reaction, mediates worm immunity by activating eosiniphils
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IgE
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ANA
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SLE
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AntidsDNA, anti Smith
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SLE
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antihistone
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drug enduced lupus
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antihistone
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drug enduced lupus
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anti IgG ( rheumatoid factor)
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rheumatoid arthritis
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anticentromere
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scerloderma- CREST
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ati Scl-70 ( anti DNA topoisomerase I)
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diffuse scerloderma
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antimitochondrial
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primary biliary cirrhosis
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antigliadin, antiendomysial
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celiac
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antibasement membrane
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goodpastures
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anti demoglein
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pemphigus vulgaris
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antimicrosomial, antithyroglobulin
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hashimotos thyroiditis
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anti Jo -1
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polumyositis, dermatomyosistis
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anti SSA ( anti Ro) anti SS-B (anti La)
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sjogrens syndrome
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anti U 1 RNP (ribonucleoprotein)
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mixed connective tissue disease
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anti smooth muscle
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autoimmune hepatitis
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antiglutamate decarboxylase
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type I diabetes mellitus
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c- ANCA
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Wegeners gramulomatosis
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pANCA
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othe vasculitides
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cytokine promotes B cell growth and differentiation
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IL 4 IL 5
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produced by Th1
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IL2 TNF gamma
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produced by Th2
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IL 4 IL 5 IL 10
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involved in growth of eosinophils
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IL 5
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inhibits macrophage activation
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IL 10
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pyogenes scereted by monocytes and macrophages
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IL 1 IL 6 TNF alpha
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inhibits Th2
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TNF gamma
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released by viruses
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TNF alpha TNF beta
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drugs that are composed of antibodies against TNF
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infliximab
etanercept adalimumab |
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precursor for 6 - mercaptopurine
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azothioprine
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may prevent nephrotoxicity with mannitol diuresis
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cyclosporine
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antibody that binds to CD3 on T cells
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muromonab
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antibody that binds IL-2 receptor on activated T cells
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daclizumab
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inhibits iosine monophosphate IMP dehydrogenase
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mycophenylate mofetil
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inhibits calcineurin resulting in the loss of IL-2 production and blockage of T cell differentiation
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cyclosporine
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bindng FK binding protein leading to loss of IL-2 production
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tacrolimus
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binding FKBP12 leading to inhibition of mTOR and T cell proliferation
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sirolimus
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used for lupus nephritis
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mycophenylate mofetil
azothioprine cyclosporine |
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metabolized by xanthine oxidase therefore increasing allopurinol toxicity
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azothioprine
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