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14 Cards in this Set
- Front
- Back
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ANTIMETABOLITE
Folic Acid Analog that causes myelosuppression |
Methotrexate
Leucovorin helps with myelosuppression Macrovesicular fatty change in liver |
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ANTIMETABOLITE
Pyrimidine analog that inhibits thymidylate synthase |
5-FU
synergy with MTX RESCUE with thymidine |
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ANTIMETABOLITE
Purine analog, activated by HGPRTase Metabolized by zanthine oxidase |
6-Mercaptopurine
*inc. toxicity with allopurinol |
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ANTIMETABOLITE
Pyrimidien analog that inhibits DNA polyerase |
Cytarabine
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ANTI-TUMOR METABOLITE
Intercalates in DNA, tx wilsm and ewings |
Dactinomycin
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ANTIMETABOLITE
Generate free radicals, breaks in DNA decreases replication |
Doxorubicin
CARDIOTOXIC- tx with dexrazoxane |
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ANTIMETABOLITE
induces free radials and causes pulmonary fibrosis |
Bleomycin
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ANTIMETABOLITE
inhibits topo II |
Etoposide
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ALKYLATING AGENTS
activated by liver |
Cyclophosphamide
Hemorrhagic cystitis |
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ALKYLATING AGENTS
-Nitrosoureas |
Carmustine, lomustine, semustine, streptozocin
Brain tumor |
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Testicular CA tx
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Eradicate Ball Cancer
E- etoposide B- bleomycin C- cisplatin |
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MICROTUBULE INHIBITORS
vincristine, vinblastine |
*Can't make microtubules
Cristine- neurotoxic blastine- bone marrow suppression |
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MICROTUBULE INHIBITORS
palitaxel, -taxols |
*Can't break down microtubules
hypersensitivity, myelosuppression |
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Agents which cross-link DNA
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CISPLATIN, CARBOPLATIN
- nephrotoxic, ototoxic Prevent nephrotoxicity with amifostine |
