Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
What is the MOA of dissociative anesthetics?
|
noncompetitive antagonist of NMDA receptors, which prevents glutamate from binding
|
|
What are the systemic effects of dissociative anesthetics?
|
increased intraoccular and intracranial pressure
apnystic breathing increased respiratory and salivary secretions muscle twitching (NOT relaxation) hallucinogenic effects increased HR and BP |
|
How are dissociative anesthetics metabolized?
|
via liver, excreted by kidney
emergence due to redistribution to muscle, fat *damage to liver or kidney can increase duration of action |
|
What are the dissociative anesthetics?
|
Ketamine, Tiletamine, Phencyclidine
|
|
Are dissociative anesthetics controlled substances?
|
Yes, Schedule III or higher!
Human abuse problem |
|
How is Tiletamine formulated?
|
with zolazepam
|
|
What is the relative potency of the different dissociative anesthetics?
|
Ketamine is the least potent, then Tiletamine, then Phencyclidine
|
|
What is ketamine commonly combined with?
|
guaifenesin and xylazine
|