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38 Cards in this Set

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UTI commonly caused by

E.Coli

UTI

Infection from perineal area can travel up the _____

muscosa tract intro bladder up the ureters up to kidneys

UTI

Lower UTIs:

Cystitis (bladder)


Urethritis (urethra)

UTI

Upper UTIs

Pyelonephritis (kidney)

UTI

Etiology:




more common in women

shorter ureters and closer to anus

UTI

men

prostatic hypertrophy (older men)


retention

UTI

Etiology:


Others

congenital abnormalities in children, incontinence, retention, fecal contamination

UTI

Cystitis & Urethritis - Patho

-hyperactive bladder & reduced capacity


-red, inflamed, swollen bladder walls and urethra - ulcerated

UTI

Cystitis & Urethritis - S/S

-dysuria, urgency, nocturia,


-systemic signs of infection (fever, malaise nausea, leukocytosis)


-pain in pelvic/lower abdomen area


-cloudy urine

UTI

Pyelonephritis - Patho

-one of both kidneys


-from ureter into kidney


-prulent exudate fill pelvis


-recurrent or chronic can lead to scar tissue formation ( loss of tubule function, obstruction, renal failure)

UTI

Pyelonephritis - S/S

flank/back pain, systemic: high temperature, dysuria,


Cystitis S/S* too

UTI

UTIs Treatment

antibacterial drugs (cipro), increase fluid intake,

cranberry juice (preventative measures)

Signs of systemic infection

(fever, malaise, fatigue, nausea, leukocytosis)

Inflammatory Disorders:


Glomerulonephritis - Patho

antistreptococcal antibodies formed d/t previous infection creating ANTIGEN-ANTIBODY COMPLEX causing inflammatory response in both kidney

Inflammatory

Glomerulonephritis - Etio

happens after a streptococcal infection with certain strains of group usually originate as ( Upper resp. infection, middle ear infection, "strept throat")





Inflammatory

Glomerulonephritis- S/S

-urine is dark & cloudy (d/t protein & RBC)


-facial & peri-orbiatal edema -> generalized edema


-BP elevated d/t increased renin recreation


-flank or back pain



Inflammatory

Glomerulonephritis- Treatment

-sodium restriction, (possible decrease fluid & protein intake in severe cases)


-glucocorticoids reduce inflammation


-antihypertensive reduce BP

Inflammatory

Signs of inflammation:

malaise,headache, anorexia, nausea

Inflammatory

Urinary Obstructions:


Urolithiasis (Kidney stones or Calculi)- Patho

-can develop anywhere in tract


-stone vary in sizes


-forms when there is insoluble salts or insufficient fluid intake, UTIs


-Manifestations only show when there is obstruction to flow of urine

Urinary Obstructions Urolithiasis

Obstruction of urine can lead to ___

infection, hydronephrosis with dilation of calyces, atrophy of renal tissue

Urinary Obstructions Urolithiasis

Urolithiasis (Kidney stones or Calculi)- Etiology

Calculi composed of 75% calcium salt and the rest are uric acid, rates,


calcium stone form when Ca+ lvl in urine are high d/t parathyroid tutor or metabolic disorders


-forms readily when pH of urine is highly alkaline


-inadequate fluid intake





Urinary Obstructions Urolithiasis

Urolithiasis (Kidney stones or Calculi)- Etio continue

uric acid stones develop d/t high purine diet, cancer chemo, gout

Urinary Obstructions Urolithiasis

Urolithiasis (Kidney stones or Calculi)- S/S

sometime flank pain radiating to groin, pain (nausea, vomiting, cool, moist skin, )


vigorous contraction of ureters to get stone out

Urinary Obstructions Urtholithiasis

Urolithiasis (Kidney stones or Calculi)- Treatment

-small stones passes eventually


drugs to dissolve stones


-shockwave lithotripsy/laser lithotripsy


-drugs to dissolve stones


-treat underlying cause (adjust urine pH, increase fluid intake)



Urinary Obstructions

Urinary Obstructions:


Hydronephrosis - Patho:

secondary problem caused by:


-complications of calculi


-tumors, scar tissue in kidney/ureters


-untreated large prostate


-if not treated -> chronic renal failure



Urinary Obstructions Hydronephrosis

Urinary Obstructions Hydronephrosis -

in kidney, continued build up of urine, over long time causes necrosis

Urinary Obstructions Hydronephrosis

Urinary Obstructions Hydronephrosis- Etio

Renal Cell Carcinoma: primary tumor arise from tubule (renal core) - men & smokers common




Bladder Cancer: malignant tumour of bladder

Urinary Obstructions Hydronephrosis

Urinary Obstructions Hydronephrosis - S/S

- painless hematuria initially


-dull, aching flank pain


-unexplained weights


-anemia



Urinary Obstructions Hydronephrosis

Urinary Obstructions Hydronephrosis - Treatment:

removal of kidney

Acute Renal Failure- Patho

-directly reduced blood flow, necrosis of tubule, obstruction,


-lead to reduced GFR & oliguria (reduced) or anuria ( no output)


-both kidney must be involved

Acute Renal Failure- Patho

-glomerulonephritis


-severe/prolonged circulatory shock/heart failure results in tubules necrosis


-ishemia (lack of blood supply)


-nephrotoxins (chemical/drugs)


-mechanical obstruction (calculi, tumors, blood clot) - blocking urine flow beyond kidney

Renal Failure

Acute Renal Failure- S/S

-develops rapidly


-elevated BUN & Creatinine


-metabolic acidosis & hyperkalemia


-

Renal Failure

Acute Renal Failure- Treatment

-reverse primary problem


-dialysis - maintain homeostasis, & fluid balance,

Renal Failure

Chronic Renal Failure - Patho


Stages:


Decreased renal reserve: decrease GFR, no clinical symptoms, high creatine lvls,


Renal Insufficiency:


elevated BP, decrease 20% of normal , retention of nitrogen waste,


End-Stage failure: fluid, electrolyte waste retained in body, all body system effected,

Renal Failure

Chronic Renal Failure -Etio

may result from:


-chronic kidney disease,


-congenital polycystic kidney disease


-systemic disorders


-low level exposure of nephrotoxin over time

Renal Failure

Chronic Renal Failure - S/S Early

early signs:-bone marrow depression, impaired cell function-high bp-polyuria (frequency, nocturia)-anorexia, nausea, anemia, fatigue, weight loss, exercise intolerance

Renal Failure

Chronic Renal Failure - S/S Late

Uremic signs:


-oliguria (abnormal small urine)


-peripheral neuropathy (abnormal sensation in lower limbs)


-dry, hyper pigmented, easy bruising skin


-CHF, arrhythmias


-systemic infection - pneumonia


-

Renal Failure

Chronic Renal Failure - Treatment

-drugs stimulate erythropoiesis, reduce phosphate lvls,


-hypertension, arrhythmias, heart failure & other complications


-transplant & dialysis