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29 Cards in this Set

  • Front
  • Back
most common leukopenia?
due to?

leukopenia only commonly found in advanced HIV, following glucocorticoids, autoimmune dis., malnutrition, and viral infections?
neutropenia; bacterial infection

lymphopenia
another name for neutropenia?

neutropenia due to suppression of myloid cells is often accompanied by (2)?
agranulocytosis

anemia, thrombocytopenia
(low WBC,RBC)
common cause of predictable agranulocytosis?
drugs, alkylating agents and anti-metabolites
two modes of leukopenia
accellerated removal/ destruction

inadequate granulopoisis
four drugs that cause agranulocytosis
chloramphenicol, sulfonamides, chlorpramazine, thiouracil
most drug induced agranulocytosis mechanism?
Ig-mediated cell lysis
neutropenia with hypercellularity caused by which?

ineffective granulopoiesis
excess destruct. of mat neutrophils
destruction of granulo. precursers
ineffective granulopoiesis
excess destruct. of mat neutrophils
neutropenia with hyporcellularity caused by which?

ineffective granulopoiesis
excess destruct. of mat neutrophils
destruction of granulo. precursers
destruction of granulocyte precursers
most serious infection giving rise to agranulocytosis have blood count of?
less than 500/ mm3
floowing myelosuprressive therapy treat w/ ? to elevate counts
G-CSF
three types of lymphoid neoplasms?
B-cell (Burkitt's)
T-cell and NK
Hodgkins
what is Lymphoma?
leukemia?
cancer of lymph nodes/ thymus

cancer of the blood/ bone marrow
Neutrophils Like Making Everything Better.

state the % of each type of blood cells in peripheral smears.
Neutrophils 60%
Like (lymphocytes) 30%
Making (macrophages) 6%
Everything (eosinophils) 3%
Better (Basophils) 1%
whats happening in Acute myelogenous Leukemia?

myelodysplastic syndrome?
immature progenitor cells are accumulating in the bone marrow

ineffective hematopoiesis / cytopenia
most lymphomas arise from germinal center B-cells ,why?
inherent genome instability during recombination events
etiologies of white cell neoplasia (5)?
chromo translocation
inherited genetics
viruses(EBV,HTLV1,KSHV)
environmental (H. pylori)
Iatrogenic (chemotherapy, drugs)
leukemias often present as/
hematopoeitic suppression on CBC
hepato-
splenomegaly
plasma cell neoplasmeas present as?
bone destruction and fracture
five broad categories of lymphoid neoplasms?
immature precursor B-cell Lym.
mature precursor B-cell lym.
immature precursor T-cell lym.
mature T-cell and NK cell lym.
Hodgkins lymphoma
how can you tell if a lymphocyte is from a neoplasia?
the DNA will be identical instead of having a random generated antigen (gene splice)
most common lymphoid neoplasia?

least?
B-cell lymphomas

NK-cell lymphomas
how is hodgkins different than the other lymphoid neoplasms?

why does this matter?
it tends not to become disseminated, rather it can be found restricted to one group of lymph nodes.

you can use this to guide treatment and make good guess at prognosis
what is ALL?

when do the two types present?
neoplasia of pre-b or pre-t cells.
whites, boys>girls
pre-b at age 4

pre-t in adolescence
markers on a pre B-cell ALL?
TdT
CD22
CD10
CD19 (very early pre-B)
no IgM ( early pre-B)
what is philadelphia chromosome?

signifies?
t(9;22)

A.L.L.
common presenting factors in ALL and AML?
abrupt stormy onset
depression of bone marrow (fatigue)
bone pain/ tenderness
splenomegaly/ hepatomegaly
CNS signs ( headache, vomiting)
how treatable is ALL?
90% complete remission
ALL poor prognosis factors (4)?
onset before 2
onset in adolescence
blasts > 100,000
t(9;22) philadelphia chromo.
four good prognosis factors in ALL?
aged 2 to 10
low white count
early pre-B phenotype
hyperploidy or t(12;21)