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30 Cards in this Set
- Front
- Back
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What is immunological competence? |
Ability to produce an immune system |
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What is essential for normal development of the immune system? |
Thymus |
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How are T cells formed (during fetal stage) |
fetal thymus cells migrate to tissues |
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What produces B cells (during fetal stage) |
Liver and bone marrow |
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What does a 4 month fetus produce? |
IgM antibodies |
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What happens before birth? |
Maternal IgG antibodies pass through placenta providing immunity to fetus |
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What happens after birth? |
Mother's milk provides IgA antobodies Infant produces IgG antibodies through exposure to antigens
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What happens at 4/5 years? |
Antibody, B cell, and T cells levels slowly rise to adult levels |
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Name 4 types of immunological disorders? |
Autoimmunity Hypersensitivity Immunodeficiency Normal but medically inconvenient immune response |
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What is autoimmunity? |
Develop self tolerance in feral (unresponsiveness of immune system to self antigens)
--> Mistaken recognition of self antigens as being foreign
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What is the autoimmunity response? |
Activation of auto reactive CD4 T cells and auto reactive B cells |
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What results in autoimmune disease |
Activated B cells make antibodies against body cells |
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What is the spectrum of autoimmune diseases? |
Organ specific Non-organ specific (systemic) |
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What is Sjogren's Syndrome? |
Dry mouth and dry eyes |
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What is the ratio of primary to secondary sjrogens syndrome |
50/50 |
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What is Primary Sjogrens |
Systemic disease of the exocrine glands - mostly the lacrimal and salivary glands (parotid, sublingual, submandibular)
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Which of the 2 Sjogrens diseases is more severe? |
Primary |
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How is Primary sjogrens treated |
Artificial saliva and tears |
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What is secondary sjogrens? |
Sjogrens and rheumatologial condition (e.g. lupus, rheumatoid arthritis, scleroderma) |
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How are the symptoms of secondary sjogrens |
Slower progression, milder ocular symptoms |
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Who is more commonly affected in secondary sjogrens syndrome? |
Women |
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What increased risk does sjogrens syndomr give you in? |
Hodgkin lymphoma, cancer of salivary glands |
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What is hypersensitivity? |
An over-reactive or altered reaction of the immune system |
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What are the 2 classifications of hypersensitivity? |
Immediate and delayed |
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When does immediate hypersensitivity occur? |
Within minutes- hours of contact with antigen |
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What is immediate hypersensitivity due to? |
Antibody-mediated immune reaction |
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What are examples of immediate hypersensitivity? |
asthma |
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When does delayed hypersensitivity occur? |
1-several days after contact with antigen |
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Why does delayed hypersensitivity occur? |
Due to a type of cell-mediated immune reaction |
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What are examples of delayed hypersensitivity? |
TB sensitivity, contact dermatitis, orthopedic implant |
