Diseases Of Bones- Bones Part 1-Gen Pathology

Front 1

DISEASES OF BONES

BONES PART 1

Back 1

DISEASES OF BONES
BONES PART 1

Front 2

The periosteum is?

the endosteum is?

Back 2

1. dense outer connect tissue layer
2. lining the medullary cavity

Front 3

woven bone is?

Back 3

haphazard arrangement of lamellae with incr of number of osteocytes, usually present with pathology

Front 4

hematopoietic marrow is in?

Back 4

ribs, vertebrae, pelvic bones, most proximal portions of long bones

Front 5

Hormonal control--

What are the three main hormones that regulate calcium and phosphate metabolism?

Back 5

calcitonin- inhibit move of calcium from bone to blood
2. parathyroid- bone resorption
3. vit D- absorb of Ca from intestines
decrease Vit D leads to rickets in children and ostemalacia in adults

Front 6

disorders of growth and maturation

Back 6

-

Front 7

the 4 different groups are?

Back 7

1. delayed cartilgae maturation disorder
-cretinism
-morquios disease
2. bone modeling disorder
- osteopetrosis
3. Epiphyseal plate disorder
-achondroplasia
-scurvy
-osteomalacia
-kyphoscolioses
4. delayed bone maturation disorder
-osteogenesis imperfecta

Front 8

OI-brittle bone disease
etiology ?

Back 8

1. hereditary disorder of collagen synthesis leadong to formation of abn collagen
2. insufficient synthesis of type 1 collagen
3. affects hearing, blue sclera

Front 9

disorders of growth and maturation

Back 9

-

Front 10

OI pathology is?

Back 10

dec synthesis of collagen--->reduced bone formation--->thin cortex--->rarefaction of trabeculae--->pahtological fractures

Front 11

the 4 different groups are?

Back 11

1. delayed cartilgae maturation disorder
-cretinism
-morquios disease
2. bone modeling disorder
- osteopetrosis
3. Epiphyseal plate disorder
-achondroplasia
-scurvy
-osteomalacia
-kyphoscolioses
4. delayed bone maturation disorder
-osteogenesis imperfecta

Front 12

OI prevelance is?

Treatment?

Back 12

20-50,000
2.no cure, surgical Rodding- rod thru bone to strengthen
-exercise as much as possible

Front 13

OI-brittle bone disease
etiology ?

Back 13

1. hereditary disorder of collagen synthesis leadong to formation of abn collagen
2. insufficient synthesis of type 1 collagen
3. affects hearing, blue sclera

Front 14

OI pathology is?

Back 14

dec synthesis of collagen--->reduced bone formation--->thin cortex--->rarefaction of trabeculae--->pahtological fractures

Front 15

OI prevelance is?

Treatment?

Back 15

20-50,000
2.no cure, surgical Rodding- rod thru bone to strengthen
-exercise as much as possible

Front 16

disorders of growth and maturation

Back 16

-

Front 17

disorders of growth and maturation

Back 17

-

Front 18

the 4 different groups are?

Back 18

1. delayed cartilgae maturation disorder
-cretinism
-morquios disease
2. bone modeling disorder
- osteopetrosis
3. Epiphyseal plate disorder
-achondroplasia
-scurvy
-osteomalacia
-kyphoscolioses
4. delayed bone maturation disorder
-osteogenesis imperfecta

Front 19

OI-brittle bone disease
etiology ?

Back 19

1. hereditary disorder of collagen synthesis leadong to formation of abn collagen
2. insufficient synthesis of type 1 collagen
3. affects hearing, blue sclera

Front 20

the 4 different groups are?

Back 20

1. delayed cartilgae maturation disorder
-cretinism
-morquios disease
2. bone modeling disorder
- osteopetrosis
3. Epiphyseal plate disorder
-achondroplasia
-scurvy
-osteomalacia
-kyphoscolioses
4. delayed bone maturation disorder
-osteogenesis imperfecta

Front 21

OI pathology is?

Back 21

dec synthesis of collagen--->reduced bone formation--->thin cortex--->rarefaction of trabeculae--->pahtological fractures

Front 22

OI-brittle bone disease
etiology ?

Back 22

1. hereditary disorder of collagen synthesis leadong to formation of abn collagen
2. insufficient synthesis of type 1 collagen
3. affects hearing, blue sclera

Front 23

OI prevelance is?

Treatment?

Back 23

20-50,000
2.no cure, surgical Rodding- rod thru bone to strengthen
-exercise as much as possible

Front 24

OI pathology is?

Back 24

dec synthesis of collagen--->reduced bone formation--->thin cortex--->rarefaction of trabeculae--->pahtological fractures

Front 25

OI prevelance is?

Treatment?

Back 25

20-50,000
2.no cure, surgical Rodding- rod thru bone to strengthen
-exercise as much as possible

Front 26

Osteopetrosis- marble bone disease..

hereditary abnormality of?
2. overgrowth and sclerosis of bones which leads to?

Back 26

osteoclasts

2. incr density of skeleton- but still breaks easilty- obliteration of medullary cavity---> anemia

Front 27

Less bone resorption resulting in a net bone.......?
2. two patterns are?

Back 27

overgrowth
2. malignant- autosomal recessive
-benign-autosomal dominant

Front 28

ACHONDROPLASIA

Back 28

-

Front 29

achondroplasia is related to?

Back 29

dec cartilaginous growth
dwarfism
long bones are short and thick

Front 30

epidemiology is?

Back 30

most common og growth defects by abn body proportions
2. 20% cases have + family hist
3. 80% due to genetic mutation

Front 31

Achondroplasia-
manifestations are?

Back 31

limbs-- much shorter than normal
normal skull,facial bones, axial skeleton
**narrow foramen magnum and SP canal= hydrocephalus
-hi risk of repeat mid ear infection--- hearing loss

Front 32

Achondroplasia treatment is?

Back 32

no specific tx
px= most live normal life span w/ carefull attention to dangerous complication

Front 33

Osteochondroma is?

Back 33

benign mass
-defect in epihphyseal cartilage of long bone- grows laterally soft tissue, from outer hyaline cartilage, stops when epiphysis closes off

Front 34

Osteochondroma manifestations include?

Back 34

solitary(mostly), or multiple (inherited autosomal dominant)
2. dx in children(multiple)& young adults
3. men affected 3 times more than women
4. mushroom shaped mass, 3-5cm
5. asymptomatic or symptomatic: deformity, pressure
6. malignant change <1%