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11 Cards in this Set
- Front
- Back
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type 1 muscle
type 2 muscle |
red slow
white fast |
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what happens after one motor unit axon is cleaved in chronic neurogenic atrophy |
collateral axon sprouting from another neuron can take over forming giant motor units with fiber type grouping |
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for neurogenic atrophy what does early give
chronic
late |
small angular, both fibers involved
large units, fiber grouping
loss of large units -> grouped atrophy |
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what is the microscopic appearance of myasthenia graves |
simplified postsynaptic folds, compensatory proliferation of presynaptic vesicles |
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what are some general myopathic changes |
nuclei internalized
more endomysium
vacuolation |
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what is difference in dystrophinopathies and channelopathies |
dystrophinopathies - duchess and Becker ect effecting dystrophin-glycoprotein complex
channelopaties - metabolic like storage diseases or mt diseases |
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what is type 2 atrophy seen with
ATPase strain shows what |
disuse, chronic disesae, cachexia, corticosteriods
selective atrophy of type 2 fibers |
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what is inclusion body myositis
what is rod body myositis plaques made of |
degernative steroid resistant myopathy with rimmed vacuoles not caused by virus
z band like material |
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what will duchenne show on microscope |
endomysial fibrosis and fiber rounding, variation in fiber size, and small blue fibers - regeneration |
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congenital myopathies are fixed with weakness at birth and non progressive but what are three types |
central core - light core of fibers
rod body - nemaline - em micrograph shows large dark elongate bodies about size of sarcomere
centronuclear - many fibers with nucleus in center of cell |
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what does botox stop
what will an atrophic fiber be shaped as
why do ragged red fibers look so
where are the damaged fibers in dermatomyo |
synaptic nt vesicle fusion
angeled do to pressure from other fibers
compensatory mt proliferation
near the inflamed perimesium |
