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35 Cards in this Set

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DISEASE OF BONES PART 4 TUMORS
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Osteosarcoma is?

metastasis is?
most common primary malignant bone tumor
2. common form of secondary malignant bone tumors in adults
the prostate, breast, lung, kidney, and thyroid in that order are?
most common forms of Cx to metastasize to bone
bone neoplasm can be benign which include?
ivory osteoma
osteoid osteoma
echondroma
bone neoplasia can be malignant which include?
osteosarcoma
chondrosarcoma
ewings sarcoma
giant cell tumor
(osteoclastoma)
bone forming tumors are?
ivory osteoma
osteoid osteoma
osteosarcoma
cartilage forming tumors are?
enchondroma
chondrosarcoma
tumors of unknown origin are?
ewings sarcoma
giant cell tumor (osteoclastoma)
Ivory osteoma- rare benign bone tumor.
features are?

pathology?
1. bones of skull(parietal, frontal) and face
2. round, sessile mass dense lamellar---> pressure, obstruction
osteoid osteoma- small painful, benign tumor..
features include: age? sex? site?
age: below 30
sex: 2;1 males
site: cortex of DIAPHYSIS of LONG BONES
Pathoogy of osteoid osteoma:

NE appearance is?
2. Micro appearance?
1. round/oval surround by sclerotic bone- 1cm size
2. thin irreg trabeculae osteoid tissue
Clinical feature?

treatment of osteoid osteoma?
1. severe pain
2. aspirin and resection
Osteosarcoma is?
site?
predisposing factors?
most common primary malignant bone tumor
2. metaphysis of long bones, around Knee!!
3. factors: Paget's disease, exp to radiation, infection, chromosome 13 mutation
pathology of osteosarcoma?
NE appearance:
arises from undiff mesenchymal cells in?
2. erodes cortex,periosteum(new bone formation) called?
metaphysis
2. codmans triangle- with surrounding tissue
Grade 1 of osteosarcoma (50%) presents with?
formation of neoplastic bone tissue(sclerotic)
bony spicules along periosteal vessels (sunray appearance)
Grade 2 of osteosarcoma presents as?
red, soft, no matrix (osteolytic)
clinical features of osteosarcoma include?
painful swelling
rapid rate of growth
pathologoc fracture
Tx of osteosarcoma includes?
combo of surgery, chemo, radiation- lead to 5 year survival rate of 60%
cartilage forming tumor: Enchondroma - benign tumor of mature hyaline cartilage.
-
features of enchondroma include:
age?
site?
young adults
-small bones of hands and feet
Pathology of enchondroma:
NE appearance presents?
micro appearance presents?
1. encapsulated nodular mass
2. mature hyaline cartilage
Clinical features?

Treatment?
pain
swelling
EROSION--> FRACTURE
2. removal if nec.
Chondrosarcoma- a malignant tumor that originates from cartilage cells
-
features of chondrosarcoma include:
incidence?
age?
site?
incidence: second to osteosarcoma
age: 4-6 decades, ave: 45 yrs
site: axial, pelvic, scapula
Pathology of chondrosarcoma:
NE appearance ?
large, bulky, lobulated mass
area of necrosis and calcification
chondrosarcoma -
Grade 1 (well differentiated): presents with?
incr number of cells
occasional mitotic figures
Chondrosarcoma
Grade 2 presents with (poorly differentiated)
-malignant spindle shape cells
-necrosis and hemorrhage
-scant chondroid matrix
Spread of chondrosarcoma ?
blood to the lung.
Tumors of unknown origin-
Ewings sarcoma- rare, extremely malignant neoplasm of bone and soft tissue
-
Features of ewing sarcoma :
age?
sex?
site?
age: children/young adults (10-30)
sex: males2;1
site; diaphysis of long bones- femur, tibia, humerus, pelvis
Pathology of ewings sarcoma:
NE appearance?
origin: mesenchymal cells/ endothelial cells in diaphysis
extends into: cortex--> layers of subperiosteal bone form(onion-skin pattern)
surrounds soft tissue
***fleshy mass with hemorrhage and necrosis***
Ewings sarcoma originates in?
the diaphysis in the long bones
Giant cell tumor (osteoclastoma)
features include:
age?
sex?
site?
age: 20-40
sex: slight female predominance
site: epiphysis of long bone- knee, prox humerus, distal radius
giant cell tumors are lytic on radiography and when bone cut in half reveals?
irreg dark red-black hemorrhagic mass in epiphyseal region
Spread of giant cell tumors include?
potential malignant
50% reoccur after removal
20% ext into soft tissue
10% metastasis into lung