Dic

Front 1

What are some cndx that elad to DIC

Back 1

Sepsis
Trauma
Incompatible blood transfusion

Front 2

2 broad categorical manifestations of DIC

Back 2

Bleeding and thromosis

Front 3

Bleeding caused by what pathophysiological process in DIC

Back 3

Fibrinolysis and depletion of clotting factors and Plt's

Front 4

Thrombosis/ischemic S&S caused by what pathophysiological process

Back 4

Systemic release of prothrombotic mediators leading to clot formation

Front 5

DIC summarized

Back 5

Accelerated clotting in microcirculation=excess thrombin>excess conversion fibrinogen to fribrin>

Above process increases bleed risk by>concuming large amt's of coag factos such as thrombin, Plt's and factor V and VII

Front 6

What may be first indicator of DIC

Back 6

Usually asymptomatic initially with only indic being a drop in Plt cnt.

As process b/c's more progressive S&S of thrombosis may occur

Finally as thrombin and plt's are consumed, bleeding begines ot occur

Front 7

What labs decrease in DIC

Back 7

Plt cnt
Fibrinogen
All rest Inc including
PT, PTT, thrombin time, D-dimer, FDP/FSP

Front 8

List three (3) blood products that may be administered to a patient experiencing DIC and state their purpose.

Back 8

-Plt’s-correct thrombocytopenia
-Cryoprecipitate-replaces factors V, VII and fibrinogen
-FFP-Replaces all clotting factors except Plt’s and provides source of antithrombin

Front 9

Rationale behind admin of Plt's in DIC

Back 9

Cirrect thrombocytopenia

Front 10

Rationale behind admin of cryoprecipitate

Back 10

Replaces factors V, VII and fibrinogen

Front 11

Rationale behind admin of FFP in DIC

Back 11

Replaces all clotting factors (except Plt's) and provides source of antithrobmin

Front 12

When might Heparin be admin'd in DIC

Back 12

Controversial, reserved for pt's in whom thrombotic Sx's predominate OR when blood products fail to halt hemorrhage

Front 13

How id effectiveness of Heparin therapy measured in DIC

Back 13

Normalization of plasma fibrinogen AND diminished Sx's of bleeding

Front 14

This Rx may be admin in DIC when manifestations of sepsis are ID'd

Back 14

Xigris

Front 15

What is Xigris

Back 15

Activated protein C

Front 16

How does Xigris work

Back 16

Slows dvp of clotting r/t septic process