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17 Cards in this Set
- Front
- Back
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DIC
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1) accelerated normal clotting
2) results in depleted clotting factors = bleeding |
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DIC etiology
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1) tissue thromboplastin into blood (extrinsic) - embolus, OB complications
2) damage to vascular endotherlium (intrinisic) sepsis, antigen-antibody 3) stasis of blood 4) infection 5) unable to clear clotting factors |
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phases if DIC
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1) clotting
clots - organ ischemia - fibrinolysis - FSP 2) Bleeding not enough clotting factors + FSP |
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integumentary manifestation
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pettechia, echymosis, bleeding from various orifices, spontaneous bleeding
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neurological manifestation
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restless, confusion, visual complaints
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cardiovascular manifestation
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cardiac tamponade, clots, ischemia, angina
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respiratory system
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hemoptysis, ARDS
tachypnea, orthopnea |
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GI manifestations
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illius, blood shunt, hemoptysis - GI bleed
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GU system manifestations
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hematuria - late sx
oliguria, ARF, increased menstrual flow |
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PT and PTT in DIC
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prolonged
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platelets, clotting factors, fibrinogen
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reduced
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fibrinolytic tests
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fibrin split products, d-dimer
reduced |
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assessment for alteration in perfusion
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early assessment- watch for blood loss, skin, I&O for early intervention to correct underlying problem
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DIC pharmacology
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IV heparin therapy (Stop clots)
antithrombin III - heparin co-factor (stop clots) amicor - disrupts fibrinolysis xigris - activated protein C (stops FSP) hirudin - inhibits thrombin (stops clots) |
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blood products to administer
to replace clotting factors if bleeding to replace blood if bleeding |
packed RBC = RBC, reduced plasma, WBC, platelets
fresh frozen plasma - all except platelets platlets - if platelets <20,000 or <50,000 + bleeding cryoprecipitate - factor 8, fibrinogen |
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extrinsic clotting
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something outside of blood - damaged tissue
tissue thromboplastic is released "quick" patch |
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intrinsic clotting
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something in blood = clotting factors released
sepetcmia - antibodies |
