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9 Cards in this Set
- Front
- Back
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Causes of Diarrhoea |
Rotavirus damaging villi Invasive bacteria damaging epithelium Cytotoxins damaging mucosa (campylobacter) Adhesive enterotoxigenic bacteria- adhere to brush border, increase cAMP, causing Cl and Na secretion, which water follows. |
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Defining diarrhoea |
3/4 watery/soft stools per day 200g watery stool per day |
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seconday diarrhoea causes (4) |
Cindamycin- pseudomembraneous colitis Orlistat - steatorrhoea Misoprostol - via cAMP PPIs- infection |
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ORT for Diarrhoea |
Electrolyte solution (isotonic) Glucose allows Na transport via the symport |
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Antibiotics for traveller's diarrhoea |
Ciprofloxacin |
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probiotics |
Reduce antbiotic associated diarrhoea and infection duration |
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Antimotility agents (2) |
OPIOIDS - Codeine, Loperamide Reduce tone+peristalsis of GI SM, via presynaptic inhibition at mu receptors. |
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Presynaptic inhibition to treat diarrhoea |
Reduces Ach release, thus motility and transport time, allowing more H20 to be reabsorbed Loperamide (cannot penetrate BBB) Codeine - analgesic - constipation possible side effect Clonidine - alpha2 agonist - constipation |
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Antimotility agents - antimuscarinic agents |
Dicycloverine TCA- constipation is side effectvia muscarinic antagonism |
